MO2R2_MOUSE
ID MO2R2_MOUSE Reviewed; 249 AA.
AC Q6XJV6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Cell surface glycoprotein CD200 receptor 2;
DE AltName: Full=CD200 cell surface glycoprotein receptor-like 2;
DE Short=CD200 receptor-like 2;
DE AltName: Full=CD200 cell surface glycoprotein receptor-like c;
DE Short=CD200RLc;
DE AltName: Full=Cell surface glycoprotein OX2 receptor 2;
DE Flags: Precursor;
GN Name=Cd200r1l; Synonyms=Cd200r2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15187158; DOI=10.4049/jimmunol.172.12.7744;
RA Gorczynski R., Chen Z., Kai Y., Lee L., Wong S., Marsden P.A.;
RT "CD200 is a ligand for all members of the CD200R family of immunoregulatory
RT molecules.";
RL J. Immunol. 172:7744-7749(2004).
RN [2]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=15274657; DOI=10.1111/j.1600-0897.2004.00192.x;
RA Gorczynski R.M., Chen Z., Clark D.A., Kai Y., Lee L., Nachman J., Wong S.,
RA Marsden P.;
RT "Structural and functional heterogeneity in the CD200R family of
RT immunoregulatory molecules and their expression at the feto-maternal
RT interface.";
RL Am. J. Reprod. Immunol. 52:147-163(2004).
RN [3]
RP IDENTIFICATION, AND FUNCTION.
RC STRAIN=BALB/cJ;
RX PubMed=15471863; DOI=10.1074/jbc.m406997200;
RA Voehringer D., Rosen D.B., Lanier L.L., Locksley R.M.;
RT "CD200 receptor family members represent novel DAP12-associated activating
RT receptors on basophils and mast cells.";
RL J. Biol. Chem. 279:54117-54123(2004).
RN [4]
RP FUNCTION.
RX PubMed=16081818; DOI=10.4049/jimmunol.175.4.2469;
RA Hatherley D., Cherwinski H.M., Moshref M., Barclay A.N.;
RT "Recombinant CD200 protein does not bind activating proteins closely
RT related to CD200 receptor.";
RL J. Immunol. 175:2469-2474(2005).
CC -!- FUNCTION: According to PubMed:15187158 it is a receptor for the CD200
CC cell surface glycoprotein. According to PubMed:16081818 it is not a
CC receptor for the CD200/OX2 cell surface glycoprotein. Involved in the
CC recruitment or surface expression of the TYROBP receptor.
CC {ECO:0000269|PubMed:15187158, ECO:0000269|PubMed:15471863,
CC ECO:0000269|PubMed:16081818}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in bone marrow, spleen, brain, lung,
CC testis and thymus. {ECO:0000269|PubMed:15187158,
CC ECO:0000269|PubMed:15274657}.
CC -!- SIMILARITY: Belongs to the CD200R family. {ECO:0000305}.
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DR EMBL; AY230198; AAO84052.1; -; mRNA.
DR CCDS; CCDS28191.1; -.
DR RefSeq; NP_996258.1; NM_206535.1.
DR AlphaFoldDB; Q6XJV6; -.
DR SMR; Q6XJV6; -.
DR STRING; 10090.ENSMUSP00000099869; -.
DR GlyGen; Q6XJV6; 3 sites.
DR PhosphoSitePlus; Q6XJV6; -.
DR PaxDb; Q6XJV6; -.
DR PRIDE; Q6XJV6; -.
DR ProteomicsDB; 295638; -.
DR DNASU; 271375; -.
DR Ensembl; ENSMUST00000102805; ENSMUSP00000099869; ENSMUSG00000090176.
DR GeneID; 271375; -.
DR KEGG; mmu:271375; -.
DR UCSC; uc007zhv.1; mouse.
DR CTD; 271375; -.
DR MGI; MGI:3042847; Cd200r2.
DR VEuPathDB; HostDB:ENSMUSG00000090176; -.
DR eggNOG; ENOG502S9IV; Eukaryota.
DR GeneTree; ENSGT00390000014496; -.
DR HOGENOM; CLU_069156_0_1_1; -.
DR InParanoid; Q6XJV6; -.
DR OMA; QAGWCKK; -.
DR OrthoDB; 993609at2759; -.
DR PhylomeDB; Q6XJV6; -.
DR TreeFam; TF335960; -.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR BioGRID-ORCS; 271375; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q6XJV6; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q6XJV6; protein.
DR Bgee; ENSMUSG00000090176; Expressed in sensory ganglion and 21 other tissues.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0038023; F:signaling receptor activity; IDA:MGI.
DR GO; GO:0150077; P:regulation of neuroinflammatory response; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR040012; CD200R.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR21462; PTHR21462; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..249
FT /note="Cell surface glycoprotein CD200 receptor 2"
FT /id="PRO_0000346452"
FT TOPO_DOM 25..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..124
FT /note="Ig-like V-type"
FT DOMAIN 113..208
FT /note="Ig-like C2-type"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 38..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 143..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 249 AA; 27408 MW; A31AE4845764F66C CRC64;
MHALGRTPAL TLLIFIYNFV SVYTIVSVQM GTKARLCCRS IPLTKAVLIT WIIKPRGQPS
CIMAYKVETK ETNETCLGRN ITWASTPDHI PDLQISAVAL QHEGNYLCEI TTPEGNFHKV
YDLQVLVPPE VTYFLGENRT AVCEAMAGKP AAQISWTPDG DCVTKSESHS NGTVTVRSTC
HWEQNNVSAV SCIVSHSTGN QSLSIELSRG TTSTTPSLLT ILYVKMVLLG IILLKVGFAF
FQKRNVTRT
