MO2R5_MOUSE
ID MO2R5_MOUSE Reviewed; 270 AA.
AC Q8BTP3; Q8BTN8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Cell surface glycoprotein CD200 receptor 5;
DE AltName: Full=CD200 cell surface glycoprotein receptor-like 5;
DE Short=CD200 receptor-like 5;
DE AltName: Full=CD200 cell surface glycoprotein receptor-like e;
DE Short=CD200RLe;
DE AltName: Full=Cell surface glycoprotein OX2 receptor 5;
DE Flags: Precursor;
GN Name=Cd200r5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Dendritic cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=16081818; DOI=10.4049/jimmunol.175.4.2469;
RA Hatherley D., Cherwinski H.M., Moshref M., Barclay A.N.;
RT "Recombinant CD200 protein does not bind activating proteins closely
RT related to CD200 receptor.";
RL J. Immunol. 175:2469-2474(2005).
CC -!- FUNCTION: May not be a receptor for the CD200/OX2 cell surface
CC glycoprotein. {ECO:0000269|PubMed:16081818}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CD200R family. {ECO:0000305}.
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DR EMBL; AK089168; BAC40774.1; -; mRNA.
DR EMBL; AK089193; BAC40786.1; -; mRNA.
DR EMBL; AK171165; BAE42287.1; -; mRNA.
DR EMBL; BC147203; AAI47204.1; -; mRNA.
DR EMBL; BC147204; AAI47205.1; -; mRNA.
DR RefSeq; NP_795984.1; NM_177010.3.
DR AlphaFoldDB; Q8BTP3; -.
DR SMR; Q8BTP3; -.
DR GlyGen; Q8BTP3; 3 sites.
DR MaxQB; Q8BTP3; -.
DR PRIDE; Q8BTP3; -.
DR ProteomicsDB; 295697; -.
DR DNASU; 319823; -.
DR GeneID; 319823; -.
DR KEGG; mmu:319823; -.
DR MGI; MGI:2442797; F630003A18Rik.
DR InParanoid; Q8BTP3; -.
DR PhylomeDB; Q8BTP3; -.
DR PRO; PR:Q8BTP3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BTP3; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0150077; P:regulation of neuroinflammatory response; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR040012; CD200R.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR21462; PTHR21462; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..270
FT /note="Cell surface glycoprotein CD200 receptor 5"
FT /id="PRO_0000346455"
FT TOPO_DOM 26..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 39..145
FT /note="Ig-like V-type"
FT DOMAIN 134..229
FT /note="Ig-like C2-type"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 59..129
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 164..213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 129
FT /note="C -> R (in Ref. 1; BAC40786)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 270 AA; 29528 MW; EFF1DBDC0EC6317A CRC64;
MHALGRTPAL TLLIFINIFV SGSRCTDKNQ TIQNDSSSPL TQVNTTVSVQ IGTKALLCCF
SIPLTKAVLI TWIIKLRDLP SCTILYKVDT KTIETSCLDR NITWASTPDH SPELQISAVT
LQHEGTYTCE TVTPEGNFGR VYDLQVLVPP EVTYFPGKNR TAVCEAMAGK PAAQISWTPD
GDCVTTSESH SNGTVTVRST CHWEQNNVSA VSCIVSHSTG NKSLFIELNQ GSTTTTTSLL
TILYVKMVLL GIILLHVGFA FFQKRNVIRT
