ID   MOAC_AZOBR              Reviewed;          92 AA.
AC   P26944;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cyclic pyranopterin monophosphate synthase {ECO:0000250|UniProtKB:P0A738};
DE            EC=4.6.1.17 {ECO:0000250|UniProtKB:P0A738};
DE   AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000250|UniProtKB:P0A738};
DE   Flags: Fragment;
GN   Name=moaC;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Azospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29145 / DSM 1690 / IMET 11303 / Sp7;
RX   PubMed=1896020; DOI=10.1007/bf00264211;
RA   Zimmer W., Aparicio C., Elmerich C.;
RT   "Relationship between tryptophan biosynthesis and indole-3-acetic acid
RT   production in Azospirillum: identification and sequencing of a trpGDC
RT   cluster.";
RL   Mol. Gen. Genet. 229:41-51(1991).
CC   -!- FUNCTION: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-
CC       dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate
CC       (cPMP). {ECO:0000250|UniProtKB:P0A738}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic
CC         pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766;
CC         EC=4.6.1.17; Evidence={ECO:0000250|UniProtKB:P0A738};
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC       {ECO:0000250|UniProtKB:P0A738}.
CC   -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000250|UniProtKB:P0A738}.
CC   -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000305}.
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DR   EMBL; X57853; CAA40988.1; -; Genomic_DNA.
DR   PIR; S17707; S17707.
DR   AlphaFoldDB; P26944; -.
DR   SMR; P26944; -.
DR   UniPathway; UPA00344; -.
DR   GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.640; -; 1.
DR   InterPro; IPR036522; MoaC_sf.
DR   InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR   Pfam; PF01967; MoaC; 1.
DR   SUPFAM; SSF55040; SSF55040; 1.
PE   3: Inferred from homology;
KW   Lyase; Molybdenum cofactor biosynthesis.
FT   CHAIN           1..>92
FT                   /note="Cyclic pyranopterin monophosphate synthase"
FT                   /id="PRO_0000097785"
FT   BINDING         80..82
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P0A738"
FT   NON_TER         92
SQ   SEQUENCE   92 AA;  9674 MW;  48B8E62242C6E1A2 CRC64;
     MTDQPLAGFT HFDAEGRAVM VDVSGKADTE RSATARGSVL MQPETLALIL QGGVKKGDVL
     SVARLAGIMG AKRTPDLIPL CHPLMLTSVK VD