MOAC_METTH
ID MOAC_METTH Reviewed; 159 AA.
AC O26900;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Probable cyclic pyranopterin monophosphate synthase accessory protein {ECO:0000255|HAMAP-Rule:MF_01224};
DE AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000255|HAMAP-Rule:MF_01224};
GN Name=moaC {ECO:0000255|HAMAP-Rule:MF_01224}; OrderedLocusNames=MTH_809;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: Together with MoaA, is involved in the conversion of 5'-GTP
CC to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor
CC Z). {ECO:0000255|HAMAP-Rule:MF_01224}.
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_01224}.
CC -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000255|HAMAP-
CC Rule:MF_01224}.
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DR EMBL; AE000666; AAB85309.1; -; Genomic_DNA.
DR PIR; A69208; A69208.
DR AlphaFoldDB; O26900; -.
DR SMR; O26900; -.
DR STRING; 187420.MTH_809; -.
DR EnsemblBacteria; AAB85309; AAB85309; MTH_809.
DR KEGG; mth:MTH_809; -.
DR PATRIC; fig|187420.15.peg.794; -.
DR HOGENOM; CLU_074693_1_2_2; -.
DR OMA; IWDMVKS; -.
DR UniPathway; UPA00344; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd01419; MoaC_A; 1.
DR Gene3D; 3.30.70.640; -; 1.
DR HAMAP; MF_01224_A; MoaC_A; 1.
DR InterPro; IPR023045; Mo_CF_biosynth-C.
DR InterPro; IPR023047; Mo_CF_biosynth-C_arc.
DR InterPro; IPR036522; MoaC_sf.
DR InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR Pfam; PF01967; MoaC; 1.
DR SUPFAM; SSF55040; SSF55040; 1.
DR TIGRFAMs; TIGR00581; moaC; 1.
PE 3: Inferred from homology;
KW Molybdenum cofactor biosynthesis; Reference proteome.
FT CHAIN 1..159
FT /note="Probable cyclic pyranopterin monophosphate synthase
FT accessory protein"
FT /id="PRO_0000097857"
FT ACT_SITE 128
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01224"
SQ SEQUENCE 159 AA; 17754 MW; 1BD8E7BB14584DA6 CRC64;
MMIMKEFTHT DEKGVRMVDV GSKPVVRRTA TAEGHILLRE DTINLIREKK IEKGNVLATA
QIAAIVAVKR TWEIIPLCHP LPLTGVDVEF DLDDDRITAR VTVRCDGKTG VEMEAVTGVS
VALLTIWDMV KSVEKDDDGQ YPETAISNIR VIKKEKLEL
