6PGL_MOUSE
ID 6PGL_MOUSE Reviewed; 257 AA.
AC Q9CQ60; Q3TA62;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=6-phosphogluconolactonase;
DE Short=6PGL;
DE EC=3.1.1.31;
GN Name=Pgls;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Heart, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; AK003134; BAB22594.1; -; mRNA.
DR EMBL; AK003985; BAB23106.1; -; mRNA.
DR EMBL; AK172066; BAE42808.1; -; mRNA.
DR EMBL; BC006594; AAH06594.1; -; mRNA.
DR CCDS; CCDS22400.1; -.
DR RefSeq; NP_001281198.1; NM_001294269.1.
DR RefSeq; NP_079672.1; NM_025396.3.
DR AlphaFoldDB; Q9CQ60; -.
DR SMR; Q9CQ60; -.
DR BioGRID; 211269; 2.
DR STRING; 10090.ENSMUSP00000034264; -.
DR iPTMnet; Q9CQ60; -.
DR PhosphoSitePlus; Q9CQ60; -.
DR SwissPalm; Q9CQ60; -.
DR REPRODUCTION-2DPAGE; Q9CQ60; -.
DR CPTAC; non-CPTAC-3757; -.
DR EPD; Q9CQ60; -.
DR jPOST; Q9CQ60; -.
DR MaxQB; Q9CQ60; -.
DR PaxDb; Q9CQ60; -.
DR PeptideAtlas; Q9CQ60; -.
DR PRIDE; Q9CQ60; -.
DR ProteomicsDB; 285738; -.
DR TopDownProteomics; Q9CQ60; -.
DR Antibodypedia; 27708; 214 antibodies from 30 providers.
DR DNASU; 66171; -.
DR Ensembl; ENSMUST00000034264; ENSMUSP00000034264; ENSMUSG00000031807.
DR GeneID; 66171; -.
DR KEGG; mmu:66171; -.
DR UCSC; uc009meb.1; mouse.
DR CTD; 25796; -.
DR MGI; MGI:1913421; Pgls.
DR VEuPathDB; HostDB:ENSMUSG00000031807; -.
DR eggNOG; KOG3147; Eukaryota.
DR GeneTree; ENSGT00550000075110; -.
DR HOGENOM; CLU_053947_0_2_1; -.
DR InParanoid; Q9CQ60; -.
DR OMA; YQLFEFE; -.
DR OrthoDB; 1420529at2759; -.
DR PhylomeDB; Q9CQ60; -.
DR TreeFam; TF318609; -.
DR Reactome; R-MMU-71336; Pentose phosphate pathway.
DR UniPathway; UPA00115; UER00409.
DR BioGRID-ORCS; 66171; 14 hits in 74 CRISPR screens.
DR ChiTaRS; Pgls; mouse.
DR PRO; PR:Q9CQ60; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CQ60; protein.
DR Bgee; ENSMUSG00000031807; Expressed in dorsal pancreas and 256 other tissues.
DR ExpressionAtlas; Q9CQ60; baseline and differential.
DR Genevisible; Q9CQ60; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; ISO:MGI.
DR GO; GO:0048029; F:monosaccharide binding; ISO:MGI.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006098; P:pentose-phosphate shunt; ISO:MGI.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; ISO:MGI.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95336"
FT CHAIN 2..257
FT /note="6-phosphogluconolactonase"
FT /id="PRO_0000090079"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O95336"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 180
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O95336"
SQ SEQUENCE 257 AA; 27254 MW; C19AF8CFC21F01C5 CRC64;
MAAPAPSLIS VFSSPQELGA SLAQLVAQRA ASCLEGDRGR FALGLSGGSL VSMLARDLPA
AAAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SKLPIPDSQV LTINPALPVE
DAAEDYARKL RQALQGDAVP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK
PPPQRVTLTL PVLNAAQSII FVATGEGKAA VLKRILEDKE GTLPAALVQP RTGALCWFLD
EAAARLLSVP FEKHSTL
