MOAC_PYRAE
ID MOAC_PYRAE Reviewed; 244 AA.
AC Q8ZYF8;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Probable cyclic pyranopterin monophosphate synthase {ECO:0000250|UniProtKB:P0A738};
DE EC=4.6.1.17 {ECO:0000250|UniProtKB:P0A738};
DE AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000250|UniProtKB:P0A738};
GN Name=moaC; OrderedLocusNames=PAE0799;
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- FUNCTION: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-
CC dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate
CC (cPMP). {ECO:0000250|UniProtKB:P0A738}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic
CC pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766;
CC EC=4.6.1.17; Evidence={ECO:0000250|UniProtKB:P0A738};
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC {ECO:0000250|UniProtKB:P0A738}.
CC -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000250|UniProtKB:P0A738}.
CC -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000305}.
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DR EMBL; AE009441; AAL63035.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZYF8; -.
DR SMR; Q8ZYF8; -.
DR STRING; 178306.PAE0799; -.
DR EnsemblBacteria; AAL63035; AAL63035; PAE0799.
DR KEGG; pai:PAE0799; -.
DR PATRIC; fig|178306.9.peg.584; -.
DR eggNOG; arCOG01530; Archaea.
DR HOGENOM; CLU_1145254_0_0_2; -.
DR InParanoid; Q8ZYF8; -.
DR OMA; WQTGVEM; -.
DR UniPathway; UPA00344; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.640; -; 1.
DR InterPro; IPR036522; MoaC_sf.
DR InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR Pfam; PF01967; MoaC; 1.
DR SUPFAM; SSF55040; SSF55040; 2.
PE 3: Inferred from homology;
KW Lyase; Molybdenum cofactor biosynthesis; Reference proteome.
FT CHAIN 1..244
FT /note="Probable cyclic pyranopterin monophosphate synthase"
FT /id="PRO_0000097859"
FT ACT_SITE 220
FT /evidence="ECO:0000250|UniProtKB:P0A738"
SQ SEQUENCE 244 AA; 26743 MW; 26625E4763FDA48C CRC64;
MIVDISKKPD VFRYARASAN ADVKKCNTAV AAKAATVASR YLPFLHPLPL SATAWCKDGK
FYVEGIAHWQ TGVEMDVLFG VLVGLLGSGA VKIENLRVEI KQKQTTPPII ENVNTSEAPI
TREGDLVASA YGRMKVVNLD IVKNPVEKGH PIYAAQTAAA LNAKRLCELL GGPCPSVQHF
KIEIITSDSV EVRTFIKARD ITPAPEALFS AGVALLTIWD MIKKYEKDEN GQYPYTYISE
LHLD