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MOAC_PYRAE
ID   MOAC_PYRAE              Reviewed;         244 AA.
AC   Q8ZYF8;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable cyclic pyranopterin monophosphate synthase {ECO:0000250|UniProtKB:P0A738};
DE            EC=4.6.1.17 {ECO:0000250|UniProtKB:P0A738};
DE   AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000250|UniProtKB:P0A738};
GN   Name=moaC; OrderedLocusNames=PAE0799;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- FUNCTION: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-
CC       dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate
CC       (cPMP). {ECO:0000250|UniProtKB:P0A738}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic
CC         pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766;
CC         EC=4.6.1.17; Evidence={ECO:0000250|UniProtKB:P0A738};
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC       {ECO:0000250|UniProtKB:P0A738}.
CC   -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000250|UniProtKB:P0A738}.
CC   -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000305}.
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DR   EMBL; AE009441; AAL63035.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZYF8; -.
DR   SMR; Q8ZYF8; -.
DR   STRING; 178306.PAE0799; -.
DR   EnsemblBacteria; AAL63035; AAL63035; PAE0799.
DR   KEGG; pai:PAE0799; -.
DR   PATRIC; fig|178306.9.peg.584; -.
DR   eggNOG; arCOG01530; Archaea.
DR   HOGENOM; CLU_1145254_0_0_2; -.
DR   InParanoid; Q8ZYF8; -.
DR   OMA; WQTGVEM; -.
DR   UniPathway; UPA00344; -.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.640; -; 1.
DR   InterPro; IPR036522; MoaC_sf.
DR   InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR   Pfam; PF01967; MoaC; 1.
DR   SUPFAM; SSF55040; SSF55040; 2.
PE   3: Inferred from homology;
KW   Lyase; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..244
FT                   /note="Probable cyclic pyranopterin monophosphate synthase"
FT                   /id="PRO_0000097859"
FT   ACT_SITE        220
FT                   /evidence="ECO:0000250|UniProtKB:P0A738"
SQ   SEQUENCE   244 AA;  26743 MW;  26625E4763FDA48C CRC64;
     MIVDISKKPD VFRYARASAN ADVKKCNTAV AAKAATVASR YLPFLHPLPL SATAWCKDGK
     FYVEGIAHWQ TGVEMDVLFG VLVGLLGSGA VKIENLRVEI KQKQTTPPII ENVNTSEAPI
     TREGDLVASA YGRMKVVNLD IVKNPVEKGH PIYAAQTAAA LNAKRLCELL GGPCPSVQHF
     KIEIITSDSV EVRTFIKARD ITPAPEALFS AGVALLTIWD MIKKYEKDEN GQYPYTYISE
     LHLD
 
 
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