MOAC_RHOCA
ID MOAC_RHOCA Reviewed; 77 AA.
AC Q9X5W6;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Cyclic pyranopterin monophosphate synthase {ECO:0000250|UniProtKB:P0A738};
DE EC=4.6.1.17 {ECO:0000250|UniProtKB:P0A738};
DE AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000250|UniProtKB:P0A738};
DE Flags: Fragment;
GN Name=moaC;
OS Rhodobacter capsulatus (Rhodopseudomonas capsulata).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Rhodobacter.
OX NCBI_TaxID=1061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 938 / 37b4;
RX PubMed=10411269; DOI=10.1099/13500872-145-6-1421;
RA Solomon P.S., Shaw A.L., Lane I., Hanson G.R., Palmer T., McEwan A.G.;
RT "Characterization of a molybdenum cofactor biosynthetic gene cluster in
RT Rhodobacter capsulatus which is specific for the biogenesis of
RT dimethylsulfoxide reductase.";
RL Microbiology 145:1421-1429(1999).
CC -!- FUNCTION: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-
CC dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate
CC (cPMP). {ECO:0000250|UniProtKB:P0A738}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic
CC pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766;
CC EC=4.6.1.17; Evidence={ECO:0000250|UniProtKB:P0A738};
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC {ECO:0000250|UniProtKB:P0A738}.
CC -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000250|UniProtKB:P0A738}.
CC -!- MISCELLANEOUS: Seems to be specific for the biogenesis of DMSO
CC reductase.
CC -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000305}.
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DR EMBL; AF128444; AAD21204.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9X5W6; -.
DR SMR; Q9X5W6; -.
DR UniPathway; UPA00344; -.
DR GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.640; -; 1.
DR InterPro; IPR036522; MoaC_sf.
DR InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR Pfam; PF01967; MoaC; 1.
DR SUPFAM; SSF55040; SSF55040; 1.
PE 3: Inferred from homology;
KW Lyase; Molybdenum cofactor biosynthesis.
FT CHAIN 1..>77
FT /note="Cyclic pyranopterin monophosphate synthase"
FT /id="PRO_0000097823"
FT NON_TER 77
SQ SEQUENCE 77 AA; 8227 MW; 99E1671C3EFC50FB CRC64;
MVDVSDKVET KRTAVAEGRV VMRPETLALV IAGRAGKGDV LGIARVAGIM AAKRTADPKN
SKSFSRVLLE RPRAHSI