ID   MOAD_MYCTU              Reviewed;          83 AA.
AC   L7N6B4; I6XG86;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Molybdopterin synthase sulfur carrier subunit {ECO:0000255|RuleBase:RU362014, ECO:0000303|PubMed:20844580};
GN   Name=moaD1; OrderedLocusNames=Rv3112; ORFNames=LH57_16990;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Beijing GC1237;
RX   PubMed=20844580; DOI=10.1371/journal.ppat.1001100;
RA   Brodin P., Poquet Y., Levillain F., Peguillet I., Larrouy-Maumus G.,
RA   Gilleron M., Ewann F., Christophe T., Fenistein D., Jang J., Jang M.S.,
RA   Park S.J., Rauzier J., Carralot J.P., Shrimpton R., Genovesio A.,
RA   Gonzalo-Asensio J.A., Puzo G., Martin C., Brosch R., Stewart G.R.,
RA   Gicquel B., Neyrolles O.;
RT   "High content phenotypic cell-based visual screen identifies Mycobacterium
RT   tuberculosis acyltrehalose-containing glycolipids involved in phagosome
RT   remodeling.";
RL   PLoS Pathog. 6:E1001100-E1001100(2010).
CC   -!- FUNCTION: Involved in sulfur transfer in the conversion of
CC       molybdopterin precursor Z to molybdopterin (By similarity). Probably
CC       plays a role in host phagosome maturation arrest (PubMed:20844580).
CC       {ECO:0000250|UniProtKB:Q6YVX4, ECO:0000255|RuleBase:RU362014,
CC       ECO:0000305|PubMed:20844580}.
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC       {ECO:0000255|RuleBase:RU362014}.
CC   -!- DISRUPTION PHENOTYPE: Grows normally in liquid culture, traffics into
CC       host (human and mouse) acidified compartments early after phagocytosis,
CC       suggesting it no longer arrests phagosome maturation as well as wild-
CC       type, impaired growth in mouse macrophages (PubMed:20844580).
CC       {ECO:0000269|PubMed:20844580}.
CC   -!- SIMILARITY: Belongs to the MoaD family. {ECO:0000305}.
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DR   EMBL; CP009480; AIR15894.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP45922.1; -; Genomic_DNA.
DR   RefSeq; WP_003899918.1; NZ_NVQJ01000011.1.
DR   RefSeq; YP_177928.1; NC_000962.3.
DR   AlphaFoldDB; L7N6B4; -.
DR   SMR; L7N6B4; -.
DR   STRING; 83332.Rv3112; -.
DR   PaxDb; L7N6B4; -.
DR   DNASU; 888897; -.
DR   GeneID; 888897; -.
DR   KEGG; mtu:Rv3112; -.
DR   PATRIC; fig|83332.12.peg.3471; -.
DR   TubercuList; Rv3112; -.
DR   eggNOG; COG1977; Bacteria.
DR   HOGENOM; CLU_187633_0_0_11; -.
DR   PhylomeDB; L7N6B4; -.
DR   UniPathway; UPA00344; -.
DR   PHI-base; PHI:7749; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR044672; MOCS2A.
DR   InterPro; IPR016155; Mopterin_synth/thiamin_S_b.
DR   InterPro; IPR003749; ThiS/MoaD-like.
DR   PANTHER; PTHR33359; PTHR33359; 1.
DR   Pfam; PF02597; ThiS; 1.
DR   SUPFAM; SSF54285; SSF54285; 1.
PE   3: Inferred from homology;
KW   Molybdenum cofactor biosynthesis; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..83
FT                   /note="Molybdopterin synthase sulfur carrier subunit"
FT                   /id="PRO_0000438347"
SQ   SEQUENCE   83 AA;  9188 MW;  6EE1751F2A36810C CRC64;
     MIKVNVLYFG AVREACDETP REEVEVQNGT DVGNLVDQLQ QKYPRLRDHC QRVQMAVNQF
     IAPLSTVLGD GDEVAFIPQV AGG