ID   MOAE_KLEAE              Reviewed;         257 AA.
AC   P54795;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein MoaE;
GN   Name=moaE;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W70;
RX   PubMed=7590328; DOI=10.1016/0378-1119(95)00400-z;
RA   Azakami H., Sugino H., Iwata N., Yokoro N., Yamashita M., Murooka Y.;
RT   "A Klebsiella aerogenes moaEF operon is controlled by the positive MoaR
RT   regulator of the monoamine regulon.";
RL   Gene 164:89-94(1995).
CC   -!- FUNCTION: Might catalyze the conversion of monoamine compounds or their
CC       metabolites.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; D28533; BAA05889.1; -; Genomic_DNA.
DR   AlphaFoldDB; P54795; -.
DR   SMR; P54795; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..257
FT                   /note="Protein MoaE"
FT                   /id="PRO_0000054725"
FT   REGION          75..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        145
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         6..29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         132
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  26294 MW;  AEDB39EE5C50C338 CRC64;
     MARVVVITGG GTGIGAACAR LMHPAGERVF ITGRRDAVRA VANETGATAL VAMPPTARCG
     ASGCCRRSST RPAGLMSSSA APAGWATAPP PRPATANERE ALDGNLTSAF ASVRACLPSL
     IARRGNVLFV ASIASLAAGP QACGYVTAKH ALIGLMRSVA RDYGPQGVRA NAICPGWVTT
     PMADEEMHPL MQAEGLSLTE AYQRVCRDVP LRRPASPEEI AQACQFLCSP QAAIISGATL
     VADGGASIVD VPTLAFA