MOB1A_MEDSF
ID MOB1A_MEDSF Reviewed; 215 AA.
AC Q949G5; Q6KC85;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=MOB kinase activator-like 1A;
DE AltName: Full=Mob1 homolog 1A;
DE AltName: Full=Mps one binder kinase activator-like 1A;
DE AltName: Full=MsMob1-1 {ECO:0000303|PubMed:16240174};
DE AltName: Full=MsMob1-2 {ECO:0000303|PubMed:16240174};
DE AltName: Full=MsMob1-3 {ECO:0000303|PubMed:16240174};
DE AltName: Full=MsMob1-A {ECO:0000303|PubMed:16460730};
GN Name=MOB1-A {ECO:0000303|PubMed:16460730};
GN Synonyms=MOB1A {ECO:0000303|PubMed:19468312};
OS Medicago sativa subsp. falcata (Sickle medic) (Medicago falcata).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3878;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX DOI=10.1007/s00497-001-0108-2;
RA Barcaccia G., Varotto S., Albertini E., Porceddu A., Meneghetti S.,
RA Parrini P., Lucchin M.;
RT "Analysis of gene expression during flowering in apomeiotic mutants of
RT Medicago spp.: cloning of ESTs and candidate genes for 2n eggs.";
RL Sex. Plant Reprod. 14:233-238(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Flower bud;
RX PubMed=16240174; DOI=10.1007/s11103-005-8104-9;
RA Citterio S., Albertini E., Varotto S., Feltrin E., Soattin M., Marconi G.,
RA Sgorbati S., Lucchin M., Barcaccia G.;
RT "Alfalfa Mob 1-like genes are expressed in reproductive organs during
RT meiosis and gametogenesis.";
RL Plant Mol. Biol. 58:789-807(2005).
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=16460730; DOI=10.1016/j.yexcr.2005.12.032;
RA Citterio S., Piatti S., Albertini E., Aina R., Varotto S., Barcaccia G.;
RT "Alfalfa Mob1-like proteins are involved in cell proliferation and are
RT localized in the cell division plane during cytokinesis.";
RL Exp. Cell Res. 312:1050-1064(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19468312;
RA Vitulo N., Vezzi A., Galla G., Citterio S., Marino G., Ruperti B.,
RA Zermiani M., Albertini E., Valle G., Barcaccia G.;
RT "Characterization and evolution of the cell cycle-associated mob domain-
RT containing proteins in eukaryotes.";
RL Evol. Bioinform. Online 3:121-158(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, phragmoplast.
CC Note=Concentrated in punctuate and fibrillar structures during G2 and M
CC phases. Localized to the cell division plane during cytokinesis.
CC {ECO:0000269|PubMed:16460730}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=MsMob1-1;
CC IsoId=Q949G5-1; Sequence=Displayed;
CC Name=2; Synonyms=MsMob1-2, MsMob1-3;
CC IsoId=Q949G5-2; Sequence=VSP_057513, VSP_057514;
CC -!- TISSUE SPECIFICITY: Isoform 1 is constitutively expressed
CC (PubMed:16240174, PubMed:16460730). Isoform 2 is specifically expressed
CC in flowers bud during sporogenesis and gametogenesis (PubMed:16240174).
CC {ECO:0000269|PubMed:16240174, ECO:0000269|PubMed:16460730}.
CC -!- DEVELOPMENTAL STAGE: Mostly expressed in actively proliferating tissues
CC (PubMed:16460730). Specifically expressed in degenerating megaspores of
CC normal ovules and in enlarged megaspore mother cells and embryo sacs of
CC apomeiotic ovules. Also detected in microspore tetrads at the beginning
CC of pollen development as well as in tapetum cells of anthers undergoing
CC programmed cell death (PCD) to allow pollen dispersal at maturity
CC (PubMed:16240174). {ECO:0000269|PubMed:16240174,
CC ECO:0000269|PubMed:16460730}.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
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DR EMBL; AJ319713; CAC41010.2; -; mRNA.
DR EMBL; AJ635581; CAG25780.1; -; mRNA.
DR EMBL; AJ635582; CAG25781.1; -; Genomic_DNA.
DR EMBL; AJ635583; CAG25782.1; -; Genomic_DNA.
DR AlphaFoldDB; Q949G5; -.
DR SMR; Q949G5; -.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0009524; C:phragmoplast; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Metal-binding; Zinc.
FT CHAIN 1..215
FT /note="MOB kinase activator-like 1A"
FT /id="PRO_0000432417"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 80
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P40484"
FT BINDING 85
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P40484"
FT BINDING 162
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P40484"
FT BINDING 167
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P40484"
FT VAR_SEQ 141..147
FT /note="FPPNFRD -> LAKTLKQ (in isoform 2)"
FT /id="VSP_057513"
FT VAR_SEQ 148..215
FT /note="Missing (in isoform 2)"
FT /id="VSP_057514"
FT CONFLICT 123
FT /note="I -> M (in Ref. 2; CAG25780/CAG25782)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 215 AA; 24631 MW; D268DBB0D7F5B452 CRC64;
MSLFGLGSRN QKTFRPKKSA PTGSKGAQLQ KHIDATLGSG NLREAVKLPP GEDINEWLAV
NTVDFFNQVN TMFGTLTEFC TPSNCPTMTA GPKYEYRWAD GVTIKKPIEV SAPKYVEYLM
DWIESQLDDE TIFPQRLGAP FPPNFRDVVK TIFKRLFRVY AHVYHSHFQK IVSLKEEAHL
NTCFKHFVLF TWEFRLIEKA ELAPLEDLVD SIIQL
