MOB1_SCHPO
ID MOB1_SCHPO Reviewed; 210 AA.
AC O94360;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Maintenance of ploidy protein mob1;
GN Name=mob1; ORFNames=SPBC428.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH SID2, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=SP2198;
RX PubMed=10769201; DOI=10.1242/jcs.113.10.1695;
RA Salimova E., Sohrmann M., Fournier N., Simanis V.;
RT "The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and
RT functions in signalling the onset of septum formation.";
RL J. Cell Sci. 113:1695-1704(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Has a role in promoting the onset of septum formation during
CC the latter stages of mitosis. {ECO:0000269|PubMed:10769201}.
CC -!- SUBUNIT: Interacts with sid2. {ECO:0000269|PubMed:10769201}.
CC -!- INTERACTION:
CC O94360; Q09898: sid2; NbExp=3; IntAct=EBI-1563433, EBI-1563447;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, spindle pole body {ECO:0000269|PubMed:10769201}. Note=Spindle
CC pole body throughout mitosis, relocates to the medial ring during
CC interphase.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
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DR EMBL; CU329671; CAA22288.1; -; Genomic_DNA.
DR PIR; T40465; T40465.
DR RefSeq; NP_595191.1; NM_001021098.2.
DR AlphaFoldDB; O94360; -.
DR SMR; O94360; -.
DR BioGRID; 277362; 29.
DR IntAct; O94360; 2.
DR STRING; 4896.SPBC428.13c.1; -.
DR MaxQB; O94360; -.
DR PaxDb; O94360; -.
DR EnsemblFungi; SPBC428.13c.1; SPBC428.13c.1:pep; SPBC428.13c.
DR GeneID; 2540845; -.
DR KEGG; spo:SPBC428.13c; -.
DR PomBase; SPBC428.13c; mob1.
DR VEuPathDB; FungiDB:SPBC428.13c; -.
DR eggNOG; KOG0440; Eukaryota.
DR HOGENOM; CLU_038321_3_2_1; -.
DR InParanoid; O94360; -.
DR OMA; HYPVIVH; -.
DR PhylomeDB; O94360; -.
DR PRO; PR:O94360; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0031097; C:medial cortex; IDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0034973; C:Sid2-Mob1 complex; IPI:PomBase.
DR GO; GO:0030295; F:protein kinase activator activity; IGI:PomBase.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:1903473; P:positive regulation of mitotic actomyosin contractile ring contraction; IMP:PomBase.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0031031; P:positive regulation of septation initiation signaling; IMP:PomBase.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW Reference proteome; Septation.
FT CHAIN 1..210
FT /note="Maintenance of ploidy protein mob1"
FT /id="PRO_0000193580"
SQ SEQUENCE 210 AA; 24744 MW; 7C95B368264C6EAF CRC64;
MFGFSNKTAK TFRVRKTEAG TKHYQLRQYA EATLGSGSLM EAVKLPKGED LNEWIAMNTM
DFYTQINMLY GTITEFCTAA SCPQMNAGPS YEYYWQDDKI YTKPTRMSAP DYINNLLDWT
QEKLDDKKLF PTEIGVEFPK NFRKVIQQIF RRLFRIYAHI YCSHFHVMVA MELESYLNTS
FKHFVFFCRE FGLMDNKEYA PMQDLVDSMV
