MOB2_DROPS
ID MOB2_DROPS Reviewed; 562 AA.
AC Q2LZ59;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=MOB kinase activator-like 2;
DE AltName: Full=Mob as tumor suppressor protein 2;
DE AltName: Full=Mps one binder kinase activator-like 2;
GN Name=Mob1 {ECO:0000250|UniProtKB:Q8IQG1}; ORFNames=GA11155;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required for the normal morphogenesis of a variety of
CC polarized outgrowths including epidermal hairs, bristles, arista
CC laterals, and dendrites. {ECO:0000250|UniProtKB:Q8IQG1}.
CC -!- SUBUNIT: Interacts with and activates trc, also interacts with wts.
CC {ECO:0000250|UniProtKB:Q8IQG1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IQG1}. Nucleus
CC {ECO:0000250|UniProtKB:Q8IQG1}. Note=Trc colocalizes with Mob1 to the
CC cell periphery in wing cells and wing hairs.
CC {ECO:0000250|UniProtKB:Q8IQG1}.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000255}.
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DR EMBL; CH379069; EAL29650.2; -; Genomic_DNA.
DR AlphaFoldDB; Q2LZ59; -.
DR SMR; Q2LZ59; -.
DR STRING; 7237.FBpp0275415; -.
DR eggNOG; KOG0440; Eukaryota.
DR HOGENOM; CLU_022966_0_0_1; -.
DR InParanoid; Q2LZ59; -.
DR OMA; MYLWFDE; -.
DR ChiTaRS; Mob2; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000902; P:cell morphogenesis; ISS:UniProtKB.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; RNA editing; Zinc.
FT CHAIN 1..562
FT /note="MOB kinase activator-like 2"
FT /id="PRO_0000279702"
FT REGION 30..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..510
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 170
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9H8S9"
FT BINDING 175
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9H8S9"
FT BINDING 250
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9H8S9"
FT BINDING 255
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9H8S9"
SQ SEQUENCE 562 AA; 59585 MW; 3ABFC05309825A6A CRC64;
MKETLSSKVP TTRTVGVTFD SVSESKSKLK SGSVQGTTAT ATATGPPSPP SSYVIKCLLK
TARFMWQVTT IPAKIGDTLG TLYRYAQDSV DTFLCVAGKA RRKERDGDQN STDTKLYLEE
SVLERKLPEA DLKALVDLPA GLDYNEWLAS HTLALFEHVN LVYGTISEFC TQSGCADMTG
PGNRTYLWFD EKGKKTRVAA PQYIDYVMTF TQKTVSDESI FPTKYANEFP GSFESIARKI
LRLQFHVIAH LYAAHFREIA LLGLHTHLNL TFAHLTALHR RFNLIDEKET DVLRDLEVAL
RLTDDTSGQD SSSSVHEHSS SSSSPPVQHQ QHQHQQQHNN SSSTSNSTSP AEALHVNSQS
NSNSHSNSSN SHTTTASASA SLIDGDSAAP PICTQPEAGA GCKPAGSSGL LGGILGDLTS
GEFGDTTRYC TSAVPQAAAS SSASAAGPGA DGAASAALNN GAGALHLNFS NNNNNNHNLN
HLNHHHHHHH HQHHHQHHPH GHHGHQGHQG HQGHHQAPAS TTVPHSGLIQ CNAAGAVGAS
AGGGGNAVSA ATGGATSASS TA