MOB3A_HUMAN
ID MOB3A_HUMAN Reviewed; 217 AA.
AC Q96BX8; B3KTF1; O75249; Q8TF69;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=MOB kinase activator 3A;
DE AltName: Full=MOB-LAK;
DE AltName: Full=Mob1 homolog 2A;
DE AltName: Full=Mps one binder kinase activator-like 2A;
GN Name=MOB3A; Synonyms=MOBKL2A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Abe Y., Ueda N.;
RT "Plausible MOB1 homolog expressed in the activated T-cells.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Florindo C.S., Tavares A.A.;
RT "Characterization of the human Mob-1 like proteins.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May regulate the activity of kinases. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAB84554.1; Type=Miscellaneous discrepancy; Note=Chimera. There is an inclusion of DNA from another gene in position 141.; Evidence={ECO:0000305};
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DR EMBL; AB061793; BAB84554.1; ALT_SEQ; mRNA.
DR EMBL; AJ580635; CAE45267.1; -; mRNA.
DR EMBL; AK095471; BAG53063.1; -; mRNA.
DR EMBL; AC005328; AAC27672.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC015049; AAH15049.1; -; mRNA.
DR CCDS; CCDS12081.1; -.
DR RefSeq; NP_570719.1; NM_130807.2.
DR RefSeq; XP_011525985.1; XM_011527683.2.
DR AlphaFoldDB; Q96BX8; -.
DR SMR; Q96BX8; -.
DR BioGRID; 125978; 11.
DR STRING; 9606.ENSP00000349575; -.
DR iPTMnet; Q96BX8; -.
DR PhosphoSitePlus; Q96BX8; -.
DR BioMuta; MOB3A; -.
DR DMDM; 56749352; -.
DR EPD; Q96BX8; -.
DR jPOST; Q96BX8; -.
DR MassIVE; Q96BX8; -.
DR MaxQB; Q96BX8; -.
DR PaxDb; Q96BX8; -.
DR PeptideAtlas; Q96BX8; -.
DR PRIDE; Q96BX8; -.
DR ProteomicsDB; 76125; -.
DR Antibodypedia; 42277; 68 antibodies from 21 providers.
DR DNASU; 126308; -.
DR Ensembl; ENST00000357066.8; ENSP00000349575.2; ENSG00000172081.14.
DR Ensembl; ENST00000592280.1; ENSP00000466249.1; ENSG00000172081.14.
DR GeneID; 126308; -.
DR KEGG; hsa:126308; -.
DR MANE-Select; ENST00000357066.8; ENSP00000349575.2; NM_130807.3; NP_570719.1.
DR UCSC; uc002luu.4; human.
DR CTD; 126308; -.
DR DisGeNET; 126308; -.
DR GeneCards; MOB3A; -.
DR HGNC; HGNC:29802; MOB3A.
DR HPA; ENSG00000172081; Low tissue specificity.
DR neXtProt; NX_Q96BX8; -.
DR OpenTargets; ENSG00000172081; -.
DR PharmGKB; PA134901591; -.
DR VEuPathDB; HostDB:ENSG00000172081; -.
DR eggNOG; KOG1903; Eukaryota.
DR GeneTree; ENSGT01050000244898; -.
DR HOGENOM; CLU_038321_3_0_1; -.
DR InParanoid; Q96BX8; -.
DR OMA; AHMGSEA; -.
DR OrthoDB; 1127941at2759; -.
DR PhylomeDB; Q96BX8; -.
DR TreeFam; TF300789; -.
DR PathwayCommons; Q96BX8; -.
DR SignaLink; Q96BX8; -.
DR BioGRID-ORCS; 126308; 9 hits in 1084 CRISPR screens.
DR ChiTaRS; MOB3A; human.
DR GeneWiki; MOBKL2A; -.
DR GenomeRNAi; 126308; -.
DR Pharos; Q96BX8; Tdark.
DR PRO; PR:Q96BX8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96BX8; protein.
DR Bgee; ENSG00000172081; Expressed in blood and 166 other tissues.
DR ExpressionAtlas; Q96BX8; baseline and differential.
DR Genevisible; Q96BX8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..217
FT /note="MOB kinase activator 3A"
FT /id="PRO_0000193570"
FT BINDING 83
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 88
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 165
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 170
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 25464 MW; C60B6EC8A3C0AA30 CRC64;
MSNPFLKQVF NKDKTFRPKR KFEPGTQRFE LHKKAQASLN AGLDLRLAVQ LPPGEDLNDW
VAVHVVDFFN RVNLIYGTIS DGCTEQSCPV MSGGPKYEYR WQDEHKFRKP TALSAPRYMD
LLMDWIEAQI NNEDLFPTNV GTPFPKNFLQ TVRKILSRLF RVFVHVYIHH FDRIAQMGSE
AHVNTCYKHF YYFVKEFGLI DTKELEPLKE MTARMCH
