ID   MOB3B_BOVIN             Reviewed;         216 AA.
AC   Q29RK9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=MOB kinase activator 3B;
DE   AltName: Full=Mob1 homolog 2b;
DE   AltName: Full=Mps one binder kinase activator-like 2B;
GN   Name=MOB3B; Synonyms=MOBKL2B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates LATS1 expression in the Hippo signaling pathway
CC       which plays a pivotal role in organ size control and tumor suppression
CC       by restricting proliferation and promoting apoptosis.
CC       {ECO:0000250|UniProtKB:Q86TA1}.
CC   -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
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DR   EMBL; BC114128; AAI14129.1; -; mRNA.
DR   RefSeq; NP_001039956.1; NM_001046491.2.
DR   RefSeq; XP_015327903.1; XM_015472417.1.
DR   AlphaFoldDB; Q29RK9; -.
DR   SMR; Q29RK9; -.
DR   STRING; 9913.ENSBTAP00000001063; -.
DR   PaxDb; Q29RK9; -.
DR   Ensembl; ENSBTAT00000001063; ENSBTAP00000001063; ENSBTAG00000000804.
DR   Ensembl; ENSBTAT00000075784; ENSBTAP00000063777; ENSBTAG00000000804.
DR   GeneID; 540817; -.
DR   KEGG; bta:540817; -.
DR   CTD; 79817; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000804; -.
DR   VGNC; VGNC:31545; MOB3B.
DR   eggNOG; KOG1903; Eukaryota.
DR   GeneTree; ENSGT01050000244898; -.
DR   HOGENOM; CLU_038321_3_0_1; -.
DR   InParanoid; Q29RK9; -.
DR   OMA; YCNETTC; -.
DR   OrthoDB; 1127941at2759; -.
DR   TreeFam; TF300789; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000000804; Expressed in pons and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0035330; P:regulation of hippo signaling; ISS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.20.140.30; -; 1.
DR   InterPro; IPR005301; MOB_kinase_act_fam.
DR   InterPro; IPR036703; MOB_kinase_act_sf.
DR   PANTHER; PTHR22599; PTHR22599; 1.
DR   Pfam; PF03637; Mob1_phocein; 1.
DR   SMART; SM01388; Mob1_phocein; 1.
DR   SUPFAM; SSF101152; SSF101152; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..216
FT                   /note="MOB kinase activator 3B"
FT                   /id="PRO_0000247547"
FT   BINDING         82
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         169
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  25450 MW;  D66E1FA9D3CA7226 CRC64;
     MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL PSGEDQNDWV
     AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW QDDLKYKKPT ALPAPQYMNL
     LMDWIEVQIN NEDIFPTCVG VPFPKNFLQI CKKILCRLFR VFVHVYIHHF DRVIVMGAEA
     HVNTCYKHFY YFVTEMNLID RKELEPLKEM TSRMCH