MOB3B_HUMAN
ID MOB3B_HUMAN Reviewed; 216 AA.
AC Q86TA1; Q8NEB4; Q9H8V4;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=MOB kinase activator 3B;
DE AltName: Full=Mob1 homolog 2b;
DE AltName: Full=Mps one binder kinase activator-like 2B;
DE Short=MOB kinase activator-like 2B;
GN Name=MOB3B {ECO:0000312|HGNC:HGNC:23825};
GN Synonyms=C9orf35 {ECO:0000312|HGNC:HGNC:23825},
GN MOBKL2B {ECO:0000312|HGNC:HGNC:23825};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Florindo C.S., Tavares A.A.;
RT "Characterization of the human Mob-1 like proteins.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP FUNCTION, AND INDUCTION BY EMICERI.
RX PubMed=28792927; DOI=10.1038/nature23451;
RA Joung J., Engreitz J.M., Konermann S., Abudayyeh O.O., Verdine V.K.,
RA Aguet F., Gootenberg J.S., Sanjana N.E., Wright J.B., Fulco C.P.,
RA Tseng Y.Y., Yoon C.H., Boehm J.S., Lander E.S., Zhang F.;
RT "Genome-scale activation screen identifies a lncRNA locus regulating a gene
RT neighbourhood.";
RL Nature 548:343-346(2017).
CC -!- FUNCTION: Modulates LATS1 expression in the Hippo signaling pathway
CC which plays a pivotal role in organ size control and tumor suppression
CC by restricting proliferation and promoting apoptosis.
CC {ECO:0000269|PubMed:28792927}.
CC -!- INTERACTION:
CC Q86TA1; P49902: NT5C2; NbExp=3; IntAct=EBI-751703, EBI-742084;
CC Q86TA1; Q13188: STK3; NbExp=3; IntAct=EBI-751703, EBI-992580;
CC -!- INDUCTION: Expression at transcriptional level is activated by the
CC expression of the neighboring long non-coding RNA (lncRNA) EMICERI.
CC {ECO:0000269|PubMed:28792927}.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
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DR EMBL; AJ580636; CAE45268.1; -; mRNA.
DR EMBL; AL832572; CAD89934.1; -; mRNA.
DR EMBL; AK023266; BAB14497.1; -; mRNA.
DR EMBL; CR457307; CAG33588.1; -; mRNA.
DR EMBL; BC033027; AAH33027.1; -; mRNA.
DR CCDS; CCDS6520.1; -.
DR RefSeq; NP_079037.3; NM_024761.4.
DR AlphaFoldDB; Q86TA1; -.
DR SMR; Q86TA1; -.
DR BioGRID; 122912; 9.
DR IntAct; Q86TA1; 4.
DR MINT; Q86TA1; -.
DR STRING; 9606.ENSP00000262244; -.
DR iPTMnet; Q86TA1; -.
DR PhosphoSitePlus; Q86TA1; -.
DR BioMuta; MOB3B; -.
DR DMDM; 56749334; -.
DR EPD; Q86TA1; -.
DR jPOST; Q86TA1; -.
DR MassIVE; Q86TA1; -.
DR MaxQB; Q86TA1; -.
DR PaxDb; Q86TA1; -.
DR PeptideAtlas; Q86TA1; -.
DR PRIDE; Q86TA1; -.
DR ProteomicsDB; 69676; -.
DR Antibodypedia; 56611; 311 antibodies from 22 providers.
DR DNASU; 79817; -.
DR Ensembl; ENST00000262244.6; ENSP00000262244.5; ENSG00000120162.10.
DR GeneID; 79817; -.
DR KEGG; hsa:79817; -.
DR MANE-Select; ENST00000262244.6; ENSP00000262244.5; NM_024761.5; NP_079037.3.
DR UCSC; uc003zqn.4; human.
DR CTD; 79817; -.
DR DisGeNET; 79817; -.
DR GeneCards; MOB3B; -.
DR HGNC; HGNC:23825; MOB3B.
DR HPA; ENSG00000120162; Tissue enhanced (brain).
DR MIM; 617652; gene.
DR neXtProt; NX_Q86TA1; -.
DR OpenTargets; ENSG00000120162; -.
DR PharmGKB; PA134886513; -.
DR VEuPathDB; HostDB:ENSG00000120162; -.
DR eggNOG; KOG1903; Eukaryota.
DR GeneTree; ENSGT01050000244898; -.
DR HOGENOM; CLU_038321_3_0_1; -.
DR InParanoid; Q86TA1; -.
DR OMA; YCNETTC; -.
DR OrthoDB; 1127941at2759; -.
DR PhylomeDB; Q86TA1; -.
DR TreeFam; TF300789; -.
DR PathwayCommons; Q86TA1; -.
DR SignaLink; Q86TA1; -.
DR BioGRID-ORCS; 79817; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; MOB3B; human.
DR GenomeRNAi; 79817; -.
DR Pharos; Q86TA1; Tbio.
DR PRO; PR:Q86TA1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q86TA1; protein.
DR Bgee; ENSG00000120162; Expressed in inferior vagus X ganglion and 188 other tissues.
DR Genevisible; Q86TA1; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0035330; P:regulation of hippo signaling; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..216
FT /note="MOB kinase activator 3B"
FT /id="PRO_0000193572"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 164
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT CONFLICT 67
FT /note="F -> L (in Ref. 2; CAD89934)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="K -> M (in Ref. 5; AAH33027)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 216 AA; 25464 MW; 377F1FA8096103FC CRC64;
MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL PSGEDQNDWV
AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW QDDLKYKKPT ALPAPQYMNL
LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI CKKILCRLFR VFVHVYIHHF DRVIVMGAEA
HVNTCYKHFY YFVTEMNLID RKELEPLKEM TSRMCH
