MOB3C_HUMAN
ID MOB3C_HUMAN Reviewed; 216 AA.
AC Q70IA8; D3DQ22; Q0VA98; Q5TC10; Q5TC11; Q8NAZ2; Q8NF28;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=MOB kinase activator 3C;
DE AltName: Full=Mob1 homolog 2C;
DE AltName: Full=Mps one binder kinase activator-like 2C;
GN Name=MOB3C; Synonyms=MOBKL2C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Florindo C.S., Tavares A.A.;
RT "Characterization of the human Mob-1 like proteins.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-216.
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May regulate the activity of kinases. {ECO:0000250}.
CC -!- INTERACTION:
CC Q70IA8; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-9679267, EBI-7247651;
CC Q70IA8; Q9NWS6: FAM118A; NbExp=4; IntAct=EBI-9679267, EBI-8638992;
CC Q70IA8; Q9H2S9: IKZF4; NbExp=3; IntAct=EBI-9679267, EBI-1640423;
CC Q70IA8; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-9679267, EBI-2556193;
CC Q70IA8; Q6A162: KRT40; NbExp=3; IntAct=EBI-9679267, EBI-10171697;
CC Q70IA8; P49902: NT5C2; NbExp=3; IntAct=EBI-9679267, EBI-742084;
CC Q70IA8; P49585: PCYT1A; NbExp=3; IntAct=EBI-9679267, EBI-2563309;
CC Q70IA8; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-9679267, EBI-79165;
CC Q70IA8; Q16825: PTPN21; NbExp=3; IntAct=EBI-9679267, EBI-2860264;
CC Q70IA8; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-9679267, EBI-747107;
CC Q70IA8; P48775: TDO2; NbExp=3; IntAct=EBI-9679267, EBI-743494;
CC Q70IA8; Q12800: TFCP2; NbExp=3; IntAct=EBI-9679267, EBI-717422;
CC Q70IA8; Q15025: TNIP1; NbExp=3; IntAct=EBI-9679267, EBI-357849;
CC Q70IA8; Q96DT7: ZBTB10; NbExp=4; IntAct=EBI-9679267, EBI-10235384;
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03434.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC03752.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ580637; CAE45269.1; -; mRNA.
DR EMBL; AK090453; BAC03434.1; ALT_INIT; mRNA.
DR EMBL; AL136373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06899.1; -; Genomic_DNA.
DR EMBL; BC121169; AAI21170.1; -; mRNA.
DR EMBL; AK091808; BAC03752.1; ALT_INIT; mRNA.
DR CCDS; CCDS539.1; -.
DR CCDS; CCDS540.1; -.
DR RefSeq; NP_660322.2; NM_145279.4.
DR RefSeq; NP_958805.1; NM_201403.2.
DR AlphaFoldDB; Q70IA8; -.
DR SMR; Q70IA8; -.
DR BioGRID; 127181; 26.
DR IntAct; Q70IA8; 17.
DR STRING; 9606.ENSP00000271139; -.
DR iPTMnet; Q70IA8; -.
DR PhosphoSitePlus; Q70IA8; -.
DR BioMuta; MOB3C; -.
DR DMDM; 56749259; -.
DR MassIVE; Q70IA8; -.
DR PaxDb; Q70IA8; -.
DR PeptideAtlas; Q70IA8; -.
DR PRIDE; Q70IA8; -.
DR ProteomicsDB; 68557; -.
DR Antibodypedia; 32815; 97 antibodies from 21 providers.
DR DNASU; 148932; -.
DR Ensembl; ENST00000271139.13; ENSP00000271139.9; ENSG00000142961.16.
DR Ensembl; ENST00000319928.9; ENSP00000315113.3; ENSG00000142961.16.
DR Ensembl; ENST00000371940.1; ENSP00000361008.2; ENSG00000142961.16.
DR GeneID; 148932; -.
DR KEGG; hsa:148932; -.
DR MANE-Select; ENST00000319928.9; ENSP00000315113.3; NM_201403.3; NP_958805.1.
DR UCSC; uc001cqf.4; human.
DR CTD; 148932; -.
DR DisGeNET; 148932; -.
DR GeneCards; MOB3C; -.
DR HGNC; HGNC:29800; MOB3C.
DR HPA; ENSG00000142961; Low tissue specificity.
DR neXtProt; NX_Q70IA8; -.
DR OpenTargets; ENSG00000142961; -.
DR PharmGKB; PA134928770; -.
DR VEuPathDB; HostDB:ENSG00000142961; -.
DR eggNOG; KOG1903; Eukaryota.
DR GeneTree; ENSGT01050000244898; -.
DR HOGENOM; CLU_038321_3_0_1; -.
DR InParanoid; Q70IA8; -.
DR OMA; QDEHQYR; -.
DR PhylomeDB; Q70IA8; -.
DR TreeFam; TF300789; -.
DR PathwayCommons; Q70IA8; -.
DR SignaLink; Q70IA8; -.
DR BioGRID-ORCS; 148932; 16 hits in 1077 CRISPR screens.
DR GenomeRNAi; 148932; -.
DR Pharos; Q70IA8; Tdark.
DR PRO; PR:Q70IA8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q70IA8; protein.
DR Bgee; ENSG00000142961; Expressed in body of pancreas and 170 other tissues.
DR ExpressionAtlas; Q70IA8; baseline and differential.
DR Genevisible; Q70IA8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..216
FT /note="MOB kinase activator 3C"
FT /id="PRO_0000193574"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 164
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 216 AA; 25623 MW; C1FF52784622BAA4 CRC64;
MALCLKQVFA KDKTFRPRKR FEPGTQRFEL YKKAQASLKS GLDLRSVVRL PPGENIDDWI
AVHVVDFFNR INLIYGTMAE RCSETSCPVM AGGPRYEYRW QDERQYRRPA KLSAPRYMAL
LMDWIEGLIN DEEVFPTRVG VPFPKNFQQV CTKILTRLFR VFVHVYIHHF DSILSMGAEA
HVNTCYKHFY YFIREFSLVD QRELEPLREM TERICH
