MOB3C_MOUSE
ID MOB3C_MOUSE Reviewed; 216 AA.
AC Q8BJG4; Q3UFI6;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=MOB kinase activator 3C;
DE AltName: Full=Mob1 homolog 2C;
DE AltName: Full=Mps one binder kinase activator-like 2C;
GN Name=Mob3c; Synonyms=Mobkl2c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May regulate the activity of kinases. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
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DR EMBL; AK084014; BAC39097.1; -; mRNA.
DR EMBL; AK148476; BAE28575.1; -; mRNA.
DR CCDS; CCDS18497.1; -.
DR RefSeq; NP_780517.1; NM_175308.4.
DR RefSeq; XP_011238683.1; XM_011240381.1.
DR RefSeq; XP_011238684.1; XM_011240382.2.
DR AlphaFoldDB; Q8BJG4; -.
DR SMR; Q8BJG4; -.
DR STRING; 10090.ENSMUSP00000030477; -.
DR iPTMnet; Q8BJG4; -.
DR PhosphoSitePlus; Q8BJG4; -.
DR MaxQB; Q8BJG4; -.
DR PaxDb; Q8BJG4; -.
DR PRIDE; Q8BJG4; -.
DR ProteomicsDB; 291377; -.
DR Antibodypedia; 32815; 97 antibodies from 21 providers.
DR DNASU; 100465; -.
DR Ensembl; ENSMUST00000030477; ENSMUSP00000030477; ENSMUSG00000028709.
DR GeneID; 100465; -.
DR KEGG; mmu:100465; -.
DR UCSC; uc008ufk.1; mouse.
DR CTD; 148932; -.
DR MGI; MGI:2140623; Mob3c.
DR VEuPathDB; HostDB:ENSMUSG00000028709; -.
DR eggNOG; KOG1903; Eukaryota.
DR GeneTree; ENSGT01050000244898; -.
DR HOGENOM; CLU_038321_3_0_1; -.
DR InParanoid; Q8BJG4; -.
DR OMA; QDEHQYR; -.
DR OrthoDB; 1127941at2759; -.
DR PhylomeDB; Q8BJG4; -.
DR TreeFam; TF300789; -.
DR BioGRID-ORCS; 100465; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Mob3c; mouse.
DR PRO; PR:Q8BJG4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BJG4; protein.
DR Bgee; ENSMUSG00000028709; Expressed in interventricular septum and 148 other tissues.
DR ExpressionAtlas; Q8BJG4; baseline and differential.
DR Genevisible; Q8BJG4; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..216
FT /note="MOB kinase activator 3C"
FT /id="PRO_0000193575"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 164
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 216 AA; 25521 MW; 71B7A64DF09FDB0A CRC64;
MALCLKQVFA KDKTFRPRKR FEPGTQRFEL YKKAQASLKS GLDLRSVVRL PPGESIDDWI
AVHVVDFFNR INLIYGTMAE HCSESSCPVM AGGPRYEYRW QDERQYRRPA KLSAPRYMAL
LMDWIEGLIN DEDVFPTRVG VPFPKNFQQV CTKILTRLFR VFVHVYIHHF DSILSMGAEA
HVNTCYKHFY YFIQEFSLVD QRELEPLREM TERICH
