MOBB_BACSU
ID MOBB_BACSU Reviewed; 173 AA.
AC O31704;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable molybdopterin-guanine dinucleotide biosynthesis adapter protein;
DE Short=MGD biosynthesis adapter protein;
DE AltName: Full=Molybdenum cofactor biosynthesis adapter protein;
DE Short=Moco biosynthesis adapter protein;
GN Name=mobB; OrderedLocusNames=BSU14290;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Caldwell R.M., Ferrari E.;
RT "Sequence analysis of the mobA-ampS region of the Bacillus subtilis
RT chromosome.";
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: GTP-binding protein that is not required for the biosynthesis
CC of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not
CC necessary for the formation of active molybdoenzymes using this form of
CC molybdenum cofactor. May act as an adapter protein to achieve the
CC efficient biosynthesis and utilization of MGD. Displays a weak
CC intrinsic GTPase activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MobB family. {ECO:0000305}.
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DR EMBL; AF012285; AAC24903.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13302.1; -; Genomic_DNA.
DR PIR; D69659; D69659.
DR RefSeq; NP_389312.1; NC_000964.3.
DR RefSeq; WP_003232370.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O31704; -.
DR SMR; O31704; -.
DR STRING; 224308.BSU14290; -.
DR PaxDb; O31704; -.
DR PRIDE; O31704; -.
DR EnsemblBacteria; CAB13302; CAB13302; BSU_14290.
DR GeneID; 938790; -.
DR KEGG; bsu:BSU14290; -.
DR PATRIC; fig|224308.179.peg.1559; -.
DR eggNOG; COG1763; Bacteria.
DR InParanoid; O31704; -.
DR OMA; YKHRQAG; -.
DR PhylomeDB; O31704; -.
DR BioCyc; BSUB:BSU14290-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR004435; MobB_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF03205; MobB; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00176; mobB; 1.
PE 3: Inferred from homology;
KW GTP-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..173
FT /note="Probable molybdopterin-guanine dinucleotide
FT biosynthesis adapter protein"
FT /id="PRO_0000096527"
FT BINDING 17..21
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 51..56
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 99..101
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 173 AA; 19145 MW; 8F46203BAEA2B8C8 CRC64;
MALVRPFPIV QVVGFQNSGK TTFIERILEK ASEQGVHLGC LKHHGHGGEP QTLTEGKDTD
RYKAAGADVT AVEGAGVLQL TARRNWDLAR LIELYQFLET DCLLIEGFKK APYPKVVILS
EKEDLEALQA VNIIAIIYRK KEHMTEHQGL PVFHADDPVA VDFVLSQLKG ESA
