MOBB_HAEIN
ID MOBB_HAEIN Reviewed; 178 AA.
AC P44902;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Molybdopterin-guanine dinucleotide biosynthesis adapter protein;
DE Short=MGD biosynthesis adapter protein;
DE AltName: Full=Molybdenum cofactor biosynthesis adapter protein;
DE Short=Moco biosynthesis adapter protein;
GN Name=mobB; OrderedLocusNames=HI_0851;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
CC -!- FUNCTION: GTP-binding protein that is not required for the biosynthesis
CC of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not
CC necessary for the formation of active molybdoenzymes using this form of
CC molybdenum cofactor. May act as an adapter protein to achieve the
CC efficient biosynthesis and utilization of MGD. Displays a weak
CC intrinsic GTPase activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MobB family. {ECO:0000305}.
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DR EMBL; L42023; AAC22508.1; -; Genomic_DNA.
DR PIR; A64160; A64160.
DR RefSeq; NP_439011.1; NC_000907.1.
DR AlphaFoldDB; P44902; -.
DR SMR; P44902; -.
DR STRING; 71421.HI_0851; -.
DR EnsemblBacteria; AAC22508; AAC22508; HI_0851.
DR KEGG; hin:HI_0851; -.
DR PATRIC; fig|71421.8.peg.892; -.
DR eggNOG; COG1763; Bacteria.
DR HOGENOM; CLU_068199_2_1_6; -.
DR OMA; HTHHNMD; -.
DR PhylomeDB; P44902; -.
DR BioCyc; HINF71421:G1GJ1-891-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IBA:GO_Central.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR004435; MobB_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF03205; MobB; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00176; mobB; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..178
FT /note="Molybdopterin-guanine dinucleotide biosynthesis
FT adapter protein"
FT /id="PRO_0000096529"
FT BINDING 22..26
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 56..59
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 103..106
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 178 AA; 20532 MW; 456F8F8F6692174F CRC64;
MIFKVIFMNN QIPLLGITGY SGSGKTTLLE KLIPELIARH IRVSVIKHSH HNMQVDKEGK
DSWRMKEAGS SQVILANDER WAIMTETPKP VSLDYLAQQF DRTLTDLVLV EGFKQEPIPK
ILLHRQEMTK PLPEIDEYVL AVATNYPLEI DRTLLDINRI PQIADFIENW LHHFHGAR
