MOBP_HUMAN
ID MOBP_HUMAN Reviewed; 183 AA.
AC Q13875; A8K2C2; G5E945; Q13874; Q6DHZ6; Q8TBJ1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Myelin-associated oligodendrocyte basic protein;
GN Name=MOBP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND ALTERNATIVE SPLICING.
RC TISSUE=Spinal cord;
RX PubMed=7989345; DOI=10.1016/s0021-9258(18)31756-3;
RA Yamamoto Y., Mizuno R., Nishimura T., Ogawa Y., Yoshikawa H., Fujimura H.,
RA Adachi E., Kishimoto T., Yanagihara T., Sakoda S.;
RT "Cloning and expression of myelin-associated oligodendrocytic basic
RT protein. A novel basic protein constituting the central nervous system
RT myelin.";
RL J. Biol. Chem. 269:31725-31730(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in compacting or stabilizing the myelin
CC sheath, possibly by binding the negatively charged acidic phospholipids
CC of the cytoplasmic membrane. {ECO:0000250}.
CC -!- INTERACTION:
CC Q13875; Q6A162: KRT40; NbExp=3; IntAct=EBI-10230628, EBI-10171697;
CC Q13875; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10230628, EBI-10172150;
CC Q13875; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10230628, EBI-10172290;
CC Q13875; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10230628, EBI-10171774;
CC Q13875; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10230628, EBI-10172052;
CC Q13875; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10230628, EBI-16439278;
CC Q13875-3; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-12013470, EBI-12006120;
CC Q13875-3; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-12013470, EBI-10217483;
CC Q13875-3; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-12013470, EBI-12012928;
CC Q13875-3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-12013470, EBI-10172290;
CC Q13875-3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12013470, EBI-10171774;
CC Q13875-3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-12013470, EBI-10172052;
CC Q13875-3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12013470, EBI-11953334;
CC Q13875-3; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-12013470, EBI-14065470;
CC Q13875-3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12013470, EBI-3958099;
CC Q13875-3; O00560: SDCBP; NbExp=3; IntAct=EBI-12013470, EBI-727004;
CC Q13875-3; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-12013470, EBI-725997;
CC Q13875-3; P17027: ZNF23; NbExp=3; IntAct=EBI-12013470, EBI-5657766;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Present in
CC the major dense line of CNS myelin. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=OPRP2;
CC IsoId=Q13875-1; Sequence=Displayed;
CC Name=2; Synonyms=OPRP1;
CC IsoId=Q13875-2; Sequence=VSP_023935;
CC Name=3;
CC IsoId=Q13875-3; Sequence=VSP_023933, VSP_023934;
CC Name=4;
CC IsoId=Q13875-4; Sequence=VSP_055152, VSP_023935;
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DR EMBL; D28113; BAA05659.1; -; mRNA.
DR EMBL; D28114; BAA05660.1; -; mRNA.
DR EMBL; AK127034; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK290187; BAF82876.1; -; mRNA.
DR EMBL; AC092058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW64588.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW64592.1; -; Genomic_DNA.
DR EMBL; BC022471; AAH22471.1; -; mRNA.
DR EMBL; BC075796; AAH75796.1; -; mRNA.
DR EMBL; BC119694; AAI19695.1; -; mRNA.
DR EMBL; BC119695; AAI19696.1; -; mRNA.
DR CCDS; CCDS2687.1; -. [Q13875-3]
DR CCDS; CCDS2688.1; -. [Q13875-1]
DR CCDS; CCDS63598.1; -. [Q13875-4]
DR PIR; C55663; C55663.
DR RefSeq; NP_001265251.1; NM_001278322.1. [Q13875-4]
DR RefSeq; NP_001265252.1; NM_001278323.1. [Q13875-1]
DR RefSeq; NP_891980.1; NM_182935.3. [Q13875-3]
DR AlphaFoldDB; Q13875; -.
DR SMR; Q13875; -.
DR BioGRID; 110479; 22.
DR IntAct; Q13875; 16.
DR iPTMnet; Q13875; -.
DR PhosphoSitePlus; Q13875; -.
DR BioMuta; MOBP; -.
DR DMDM; 134034171; -.
DR MassIVE; Q13875; -.
DR PeptideAtlas; Q13875; -.
DR PRIDE; Q13875; -.
DR ProteomicsDB; 33825; -.
DR ProteomicsDB; 59706; -. [Q13875-1]
DR ProteomicsDB; 59707; -. [Q13875-2]
DR ProteomicsDB; 59708; -. [Q13875-3]
DR Antibodypedia; 28962; 198 antibodies from 28 providers.
DR DNASU; 4336; -.
DR Ensembl; ENST00000311042.10; ENSP00000312293.6; ENSG00000168314.19. [Q13875-4]
DR Ensembl; ENST00000383754.7; ENSP00000373261.3; ENSG00000168314.19. [Q13875-3]
DR Ensembl; ENST00000415443.5; ENSP00000388148.1; ENSG00000168314.19. [Q13875-3]
DR Ensembl; ENST00000420739.5; ENSP00000400491.1; ENSG00000168314.19. [Q13875-1]
DR Ensembl; ENST00000424090.5; ENSP00000389055.1; ENSG00000168314.19. [Q13875-1]
DR Ensembl; ENST00000428261.5; ENSP00000401312.1; ENSG00000168314.19. [Q13875-3]
DR Ensembl; ENST00000441980.6; ENSP00000388827.2; ENSG00000168314.19. [Q13875-1]
DR Ensembl; ENST00000442631.5; ENSP00000413771.1; ENSG00000168314.19. [Q13875-2]
DR Ensembl; ENST00000447324.5; ENSP00000409730.1; ENSG00000168314.19. [Q13875-3]
DR Ensembl; ENST00000452959.6; ENSP00000405549.1; ENSG00000168314.19. [Q13875-3]
DR Ensembl; ENST00000682069.1; ENSP00000506926.1; ENSG00000168314.19. [Q13875-1]
DR Ensembl; ENST00000684792.1; ENSP00000508923.1; ENSG00000168314.19. [Q13875-1]
DR GeneID; 4336; -.
DR KEGG; hsa:4336; -.
DR MANE-Select; ENST00000684792.1; ENSP00000508923.1; NM_001393704.1; NP_001380633.1.
DR UCSC; uc003cju.5; human. [Q13875-1]
DR CTD; 4336; -.
DR DisGeNET; 4336; -.
DR GeneCards; MOBP; -.
DR HGNC; HGNC:7189; MOBP.
DR HPA; ENSG00000168314; Tissue enriched (brain).
DR MIM; 600948; gene.
DR neXtProt; NX_Q13875; -.
DR OpenTargets; ENSG00000168314; -.
DR PharmGKB; PA30899; -.
DR VEuPathDB; HostDB:ENSG00000168314; -.
DR GeneTree; ENSGT00950000183138; -.
DR HOGENOM; CLU_2855470_0_0_1; -.
DR InParanoid; Q13875; -.
DR OMA; NQKFTEH; -.
DR OrthoDB; 492485at2759; -.
DR PhylomeDB; Q13875; -.
DR PathwayCommons; Q13875; -.
DR Reactome; R-HSA-8986944; Transcriptional Regulation by MECP2.
DR SignaLink; Q13875; -.
DR BioGRID-ORCS; 4336; 8 hits in 1073 CRISPR screens.
DR ChiTaRS; MOBP; human.
DR GenomeRNAi; 4336; -.
DR Pharos; Q13875; Tbio.
DR PRO; PR:Q13875; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q13875; protein.
DR Bgee; ENSG00000168314; Expressed in C1 segment of cervical spinal cord and 143 other tissues.
DR ExpressionAtlas; Q13875; baseline and differential.
DR Genevisible; Q13875; HS.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0017022; F:myosin binding; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR InterPro; IPR041282; FYVE_2.
DR Pfam; PF02318; FYVE_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..183
FT /note="Myelin-associated oligodendrocyte basic protein"
FT /id="PRO_0000281025"
FT REPEAT 97..106
FT /note="1"
FT REPEAT 107..116
FT /note="2"
FT REPEAT 117..126
FT /note="3"
FT REPEAT 127..136
FT /note="4"
FT REGION 68..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..136
FT /note="4 X 10 AA tandem repeats of P-R-S-P-P-R-S-E-R-Q"
FT COMPBIAS 98..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63327"
FT MOD_RES 109
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63327"
FT VAR_SEQ 68
FT /note="T -> TSSCQRRLSSRGEPWLPPPASFGPL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055152"
FT VAR_SEQ 70..81
FT /note="TSRRAKSPQRPK -> LKRKIRPTPKKK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023933"
FT VAR_SEQ 82..183
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023934"
FT VAR_SEQ 183
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:7989345"
FT /id="VSP_023935"
FT CONFLICT 28
FT /note="P -> R (in Ref. 5; AAH75796)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="V -> E (in Ref. 2; AK127034)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="S -> P (in Ref. 1; BAA05660)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 183 AA; 20959 MW; 81831413BCC6A041 CRC64;
MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW
ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP PRSERQPRSP PRSERQPRSP
PRSERQPRSP PRSERQPRPR PEVRPPPAKQ RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS
RFW
