ID   MOC2A_DROER             Reviewed;          90 AA.
AC   B3P6R4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Molybdopterin synthase sulfur carrier subunit {ECO:0000255|HAMAP-Rule:MF_03051};
DE   AltName: Full=Molybdenum cofactor synthesis protein 2 small subunit {ECO:0000255|HAMAP-Rule:MF_03051};
DE   AltName: Full=Molybdenum cofactor synthesis protein 2A {ECO:0000255|HAMAP-Rule:MF_03051};
DE            Short=MOCS2A {ECO:0000255|HAMAP-Rule:MF_03051};
DE   AltName: Full=Sulfur carrier protein MOCS2A {ECO:0000255|HAMAP-Rule:MF_03051};
GN   Name=Mocs2A {ECO:0000250|UniProtKB:P0C919};
GN   Synonyms=Mocs2 {ECO:0000255|HAMAP-Rule:MF_03051}; ORFNames=GG12283;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a sulfur carrier required for molybdopterin
CC       biosynthesis. Component of the molybdopterin synthase complex that
CC       catalyzes the conversion of precursor Z into molybdopterin by mediating
CC       the incorporation of 2 sulfur atoms into precursor Z to generate a
CC       dithiolene group. In the complex, serves as sulfur donor by being
CC       thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction
CC       with Mocs2B, the sulfur is then transferred to precursor Z to form
CC       molybdopterin. {ECO:0000255|HAMAP-Rule:MF_03051}.
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03051}.
CC   -!- SUBUNIT: Heterotetramer; composed of 2 small (Mocs2A) and 2 large
CC       (Mocs2B) subunits. {ECO:0000255|HAMAP-Rule:MF_03051}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03051}.
CC   -!- PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-
CC       adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then
CC       thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
CC       {ECO:0000255|HAMAP-Rule:MF_03051}.
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the large subunit (Mocs2B).
CC   -!- SIMILARITY: Belongs to the MoaD family. MOCS2A subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03051}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH954182; EDV53734.1; -; Genomic_DNA.
DR   RefSeq; XP_001981864.1; XM_001981828.2.
DR   AlphaFoldDB; B3P6R4; -.
DR   SMR; B3P6R4; -.
DR   STRING; 7220.FBpp0130829; -.
DR   EnsemblMetazoa; FBtr0132337; FBpp0130829; FBgn0104574.
DR   GeneID; 6555339; -.
DR   KEGG; der:6555339; -.
DR   eggNOG; KOG3474; Eukaryota.
DR   HOGENOM; CLU_114601_4_3_1; -.
DR   OMA; HVLFFAK; -.
DR   OrthoDB; 1631547at2759; -.
DR   PhylomeDB; B3P6R4; -.
DR   UniPathway; UPA00344; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030366; F:molybdopterin synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; ISS:UniProtKB.
DR   Gene3D; 3.10.20.30; -; 1.
DR   HAMAP; MF_03051; MOCS2A; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR044672; MOCS2A.
DR   InterPro; IPR028887; MOCS2A_euk.
DR   InterPro; IPR016155; Mopterin_synth/thiamin_S_b.
DR   InterPro; IPR003749; ThiS/MoaD-like.
DR   PANTHER; PTHR33359; PTHR33359; 1.
DR   Pfam; PF02597; ThiS; 1.
DR   SUPFAM; SSF54285; SSF54285; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Nucleotide-binding;
KW   Phosphoprotein.
FT   CHAIN           1..90
FT                   /note="Molybdopterin synthase sulfur carrier subunit"
FT                   /id="PRO_0000369311"
FT   MOD_RES         90
FT                   /note="1-thioglycine; alternate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03051"
FT   MOD_RES         90
FT                   /note="Glycyl adenylate; alternate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03051"
SQ   SEQUENCE   90 AA;  9789 MW;  848A6250B69C2C98 CRC64;
     MNADGPVVNV HVLFFAKSRE LANTPRSKVD VPTKITASDL LDLLVSRFGL ISIRDNLILA
     HNESYIDNLS DTVLFKEGDE LAIIPPLSGG