ID   6PGL_NEIMA              Reviewed;         231 AA.
AC   P63336; A1ISJ0; Q9JR64;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=pgl; OrderedLocusNames=NMA1608;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR   EMBL; AL157959; CAM08748.1; -; Genomic_DNA.
DR   RefSeq; WP_002213145.1; NC_003116.1.
DR   AlphaFoldDB; P63336; -.
DR   SMR; P63336; -.
DR   EnsemblBacteria; CAM08748; CAM08748; NMA1608.
DR   GeneID; 61281579; -.
DR   KEGG; nma:NMA1608; -.
DR   HOGENOM; CLU_053947_2_1_4; -.
DR   OMA; YQLFEFE; -.
DR   BioCyc; NMEN122587:NMA_RS08045-MON; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   PANTHER; PTHR11054; PTHR11054; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..231
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000090097"
SQ   SEQUENCE   231 AA;  24980 MW;  5EF54C495553D073 CRC64;
     MFVWHEYENA AEAAQSLADA VADALQGALD EKGGAVLAVS GGRSPIAFFN ALSQKDLDWK
     NVGITLADER IVPTVHADSN TGLVREYLLK NKAEAAMWIP MVEDGKTETE LHPDAVVDYA
     LKHYKQPDVL VLGMGNDGHT ASIFPKAPQF QTAIDGSAGV ALVHTTPVTA PHERVSMTLD
     AIAHTGHVFL AIRGEEKKAV FDQAAQGENR EYPINLVLNH QGVNCHVFYA E