MOC3_SCHPO
ID MOC3_SCHPO Reviewed; 508 AA.
AC Q9UT46; Q9UU35;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 4.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transcriptional regulatory protein moc3;
DE AltName: Full=Multicopy suppressor of overexpressed cyr1 protein 3;
GN Name=moc3; ORFNames=SPAC821.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH ZFS1, AND
RP SUBCELLULAR LOCATION.
RX PubMed=16273369; DOI=10.1007/s00294-005-0028-z;
RA Goldar M.M., Jeong H.T., Tanaka K., Matsuda H., Kawamukai M.;
RT "Moc3, a novel Zn finger type protein involved in sexual development, ascus
RT formation, and stress response of Schizosaccharomyces pombe.";
RL Curr. Genet. 48:345-355(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-55, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Induces sexual development and ascus formation. Also involved
CC in calcium homeostasis. {ECO:0000269|PubMed:16273369}.
CC -!- SUBUNIT: Interacts with zfs1. {ECO:0000269|PubMed:16273369}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227,
CC ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16273369,
CC ECO:0000269|PubMed:16823372}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA87144.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CU329670; CAB57441.2; -; Genomic_DNA.
DR EMBL; AB027840; BAA87144.1; ALT_INIT; Genomic_DNA.
DR PIR; T41718; T41718.
DR RefSeq; NP_593160.2; NM_001018558.2.
DR AlphaFoldDB; Q9UT46; -.
DR SMR; Q9UT46; -.
DR BioGRID; 280060; 106.
DR IntAct; Q9UT46; 40.
DR MINT; Q9UT46; -.
DR STRING; 4896.SPAC821.07c.1; -.
DR iPTMnet; Q9UT46; -.
DR SwissPalm; Q9UT46; -.
DR MaxQB; Q9UT46; -.
DR PaxDb; Q9UT46; -.
DR PRIDE; Q9UT46; -.
DR EnsemblFungi; SPAC821.07c.1; SPAC821.07c.1:pep; SPAC821.07c.
DR GeneID; 2543646; -.
DR KEGG; spo:SPAC821.07c; -.
DR PomBase; SPAC821.07c; moc3.
DR VEuPathDB; FungiDB:SPAC821.07c; -.
DR eggNOG; ENOG502SFTK; Eukaryota.
DR HOGENOM; CLU_536554_0_0_1; -.
DR InParanoid; Q9UT46; -.
DR OMA; CVGHAVT; -.
DR PRO; PR:Q9UT46; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; NAS:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISM:PomBase.
DR GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR GO; GO:0031139; P:positive regulation of conjugation with cellular fusion; IMP:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; NAS:PomBase.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..508
FT /note="Transcriptional regulatory protein moc3"
FT /id="PRO_0000115010"
FT DNA_BIND 46..76
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 15..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 56692 MW; 8FBC9601646CAE42 CRC64;
MNPYVSYPEI HMKRNRTGSI NSNPLYIPNP NVEPTPKPTK RRTKTGCLTC RRRRIKCDET
KPFCLNCTKT NRECEGYPNS AAQMQAMGSV SPPELSVHSA QQPLIPTSIA SSSAQTGDTF
SGSSQSNFNT NDLNQMTSSS NLSTVTPIKQ DHQKPMNLQG FPSAYQQHQY LQSNHNVPTN
NSSSATSSTK PSVQSVGQAS YPFLSSVSNF PSNFNSELFP FYFHDVVPSI CAFEFDNNIA
LHFWSVTVPQ FAQSMPCIAN SLMAFASIKK LDVFGAYSHL TRALRCPMPG PNSFEYLLVS
AFLTLTQLNL PAYDLNFCNN FIRKLSWSSS TKSNYVSLLI AMVVRELVFA ILPRGCIWGF
NGKPLSEVSV SRSHAPVSDS LFTIGLDILS QPTLSDDLHR ERMVAWRDEY HVHLYSASRS
PLTKVIDCVG HAVTKNNNDV LSGLQQLMQE ECTDIAVLRT SYLCVLSLQN VFASNSKEFK
LRAQIESHFG RLMLEHFMDC NVLNRPVL
