ID   MODB_MYCTO              Reviewed;         264 AA.
AC   P9WG12; L0TAT4; O08061; P0A624; P95156;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Molybdenum transport system permease protein ModB;
GN   Name=modB; OrderedLocusNames=MT1906;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system
CC       ModABCD for molybdenum; probably responsible for the translocation of
CC       the substrate across the membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. CysTW subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46177.1; ALT_INIT; Genomic_DNA.
DR   PIR; B70666; B70666.
DR   RefSeq; WP_003409329.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WG12; -.
DR   SMR; P9WG12; -.
DR   EnsemblBacteria; AAK46177; AAK46177; MT1906.
DR   GeneID; 45425831; -.
DR   KEGG; mtc:MT1906; -.
DR   PATRIC; fig|83331.31.peg.2050; -.
DR   HOGENOM; CLU_016047_14_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR011867; ModB_ABC.
DR   InterPro; IPR006469; NifC_ABC_porter.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   TIGRFAMs; TIGR01581; Mo_ABC_porter; 1.
DR   TIGRFAMs; TIGR02141; modB_ABC; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Molybdenum; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..264
FT                   /note="Molybdenum transport system permease protein ModB"
FT                   /id="PRO_0000428442"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          51..253
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   264 AA;  27676 MW;  D20EC44EB28DD526 CRC64;
     MHPPTDLPRW VYLPAIAGIV FVAMPLVAIA IRVDWPRFWA LITTPSSQTA LLLSVKTAAA
     STVLCVLLGV PMALVLARSR GRLVRSLRPL ILLPLVLPPV VGGIALLYAF GRLGLIGRYL
     EAAGISIAFS TAAVVLAQTF VSLPYLVISL EGAARTAGAD YEVVAATLGA RPGTVWWRVT
     LPLLLPGVVS GSVLAFARSL GEFGATLTFA GSRQGVTRTL PLEIYLQRVT DPDAAVALSL
     LLVVVAALVV LGVGARTPIG TDTR