ID   MODB_MYCTU              Reviewed;         264 AA.
AC   P9WG13; L0TAT4; O08061; P0A624; P95156;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Molybdenum transport system permease protein ModB;
GN   Name=modB; OrderedLocusNames=Rv1858; ORFNames=MTCY359.15c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RA   Laqueyrerie A.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system
CC       ModABCD for molybdenum; probably responsible for the translocation of
CC       the substrate across the membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. CysTW subfamily. {ECO:0000305}.
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DR   EMBL; X99258; CAA67643.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44624.1; -; Genomic_DNA.
DR   PIR; B70666; B70666.
DR   RefSeq; NP_216374.1; NC_000962.3.
DR   RefSeq; WP_003409329.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WG13; -.
DR   SMR; P9WG13; -.
DR   STRING; 83332.Rv1858; -.
DR   TCDB; 3.A.1.8.5; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P9WG13; -.
DR   DNASU; 885723; -.
DR   GeneID; 45425831; -.
DR   GeneID; 885723; -.
DR   KEGG; mtu:Rv1858; -.
DR   TubercuList; Rv1858; -.
DR   eggNOG; COG4149; Bacteria.
DR   OMA; MYSFIET; -.
DR   PhylomeDB; P9WG13; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR011867; ModB_ABC.
DR   InterPro; IPR006469; NifC_ABC_porter.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   TIGRFAMs; TIGR01581; Mo_ABC_porter; 1.
DR   TIGRFAMs; TIGR02141; modB_ABC; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Molybdenum; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..264
FT                   /note="Molybdenum transport system permease protein ModB"
FT                   /id="PRO_0000060116"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          51..253
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   264 AA;  27676 MW;  D20EC44EB28DD526 CRC64;
     MHPPTDLPRW VYLPAIAGIV FVAMPLVAIA IRVDWPRFWA LITTPSSQTA LLLSVKTAAA
     STVLCVLLGV PMALVLARSR GRLVRSLRPL ILLPLVLPPV VGGIALLYAF GRLGLIGRYL
     EAAGISIAFS TAAVVLAQTF VSLPYLVISL EGAARTAGAD YEVVAATLGA RPGTVWWRVT
     LPLLLPGVVS GSVLAFARSL GEFGATLTFA GSRQGVTRTL PLEIYLQRVT DPDAAVALSL
     LLVVVAALVV LGVGARTPIG TDTR