MODC2_BRADU
ID MODC2_BRADU Reviewed; 897 AA.
AC Q89EW7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Molybdenum import ATP-binding protein ModC 2 {ECO:0000255|HAMAP-Rule:MF_01705};
DE EC=7.3.2.5 {ECO:0000255|HAMAP-Rule:MF_01705};
GN Name=modC2 {ECO:0000255|HAMAP-Rule:MF_01705}; OrderedLocusNames=blr6953;
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium.
OX NCBI_TaxID=224911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- FUNCTION: Part of the ABC transporter complex ModABC involved in
CC molybdenum import. Responsible for energy coupling to the transport
CC system. {ECO:0000255|HAMAP-Rule:MF_01705}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) +
CC phosphate; Xref=Rhea:RHEA:22020, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36264,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01705};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (ModC),
CC two transmembrane proteins (ModB) and a solute-binding protein (ModA).
CC {ECO:0000255|HAMAP-Rule:MF_01705}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01705}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01705}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Molybdate
CC importer (TC 3.A.1.8) family. {ECO:0000255|HAMAP-Rule:MF_01705}.
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DR EMBL; BA000040; BAC52218.1; -; Genomic_DNA.
DR RefSeq; NP_773593.1; NC_004463.1.
DR RefSeq; WP_011089691.1; NC_004463.1.
DR AlphaFoldDB; Q89EW7; -.
DR SMR; Q89EW7; -.
DR STRING; 224911.27355234; -.
DR EnsemblBacteria; BAC52218; BAC52218; BAC52218.
DR GeneID; 64028205; -.
DR KEGG; bja:blr6953; -.
DR PATRIC; fig|224911.5.peg.7124; -.
DR eggNOG; COG1618; Bacteria.
DR eggNOG; COG4148; Bacteria.
DR HOGENOM; CLU_322557_0_0_5; -.
DR InParanoid; Q89EW7; -.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015412; F:ABC-type molybdate transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042888; F:molybdenum ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015852; ABC_transpr_ModC.
DR InterPro; IPR018912; DUF2478.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR011868; ModC_ABC_ATP-bd.
DR InterPro; IPR004606; Mop_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005116; Transp-assoc_OB_typ1.
DR PANTHER; PTHR43514:SF9; PTHR43514:SF9; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF10649; DUF2478; 1.
DR Pfam; PF03459; TOBE; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02142; modC_ABC; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51241; MODC; 1.
DR PROSITE; PS51866; MOP; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane; Molybdenum;
KW Nucleotide-binding; Reference proteome; Translocase; Transport.
FT CHAIN 1..897
FT /note="Molybdenum import ATP-binding protein ModC 2"
FT /id="PRO_0000092534"
FT DOMAIN 6..236
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01705"
FT DOMAIN 295..365
FT /note="Mop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01213"
FT REGION 823..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01705"
SQ SEQUENCE 897 AA; 96174 MW; 154C54F8D41A4D12 CRC64;
MTADGRGRID AAFRGRLGRF VLDASLSVPA TGVTAIFGPS GCGKTTIARC IAGLQRLSDG
FCAIDGEIWQ DGMAFRPAHR RPVGYVFQEP SLFPHLSVRG NLLYGAPKAA ATSIGFDEVV
ELLGLTALLG RSPHRLSGGE RQRVAIGRAL LSQPRLLLMD EPLAALDRTT KNEILPFLER
LHERLSLPVL YISHDMAEIE RFADYLVLME RGRVVGAGPL HILQSDPALP LAYSRDAAVS
IDGLVEAYDE RYGLLTLAVN GGLLHVPSHR IAVGARQRLR IAASDVSIVR ARPSESSILN
ILPARIVTQS PPGAGEVTIV LGLDSDGSGA PILSRISSRS RDLLGLSDGM AVFAQVKGVS
LVRASGCAIG NMGPTAPGQL DHCSTQDTGV RSEAGTTAMP IDFAEIDPNR VAAILYRPQD
DLDTLLADFA QDLVRAGERI GGIVQRNIKD GSGCQVGMQA IDLMTGREIS ICQPLGSGAM
ACKLDAAGLA DASVAVASAI AQDVDLIVIN KFSKQEAAGR GLRDELAGAI AAGIPVLTAV
PEKCFEAWIS FTGGIGTTLL CERQVIEAWW RDTSSRMKRM REDHDAVVAQ CIEISGALPL
VQRVVARQLV VTHDLPLDPE RAEAEVVVRG VVERTNVEVL DGAADEADEA PDAGFPVGPE
RIERLPDIGP VPRRHEALQV EREVLSPDAC LQRSAGERVD VFKEGKTKVG TVLVDRGDAE
LVEGPIVLEL HEGAPVLVEM NVGVDLQTLY EIAVRGRVAG AERRCAIGLE AFAQRRPQRD
VAFRIGGPKR DVFEPVKRFG TQPGIGKDRP VLCPAVRLDR RPLGDRSVLG PREPDAGAKG
RKRQNDPEVA HIAPCQHRRT SPHLASARDA LFGPREWISA TYPPGNMTNA ADRLLDV
