ID   6PGL_NOSS1              Reviewed;         240 AA.
AC   P46016;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=pgl; Synonyms=devB; OrderedLocusNames=alr1602;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bauer C.C., Scappino L., Haselkorn R.;
RT   "Bacterial subtracted cDNA libraries containing genes involved in the
RT   differentiation of vegetative cells to heterocysts allow a new twist on an
RT   old method of isolating developmental genes.";
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3.
CC   -!- DEVELOPMENTAL STAGE: Developmentally regulated gene in heterocyst
CC       development.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR   EMBL; U14553; AAA50355.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB77968.1; -; Genomic_DNA.
DR   PIR; AD2006; AD2006.
DR   RefSeq; WP_010995771.1; NZ_RSCN01000041.1.
DR   AlphaFoldDB; P46016; -.
DR   SMR; P46016; -.
DR   STRING; 103690.17135422; -.
DR   EnsemblBacteria; BAB77968; BAB77968; BAB77968.
DR   KEGG; ana:alr1602; -.
DR   eggNOG; COG0363; Bacteria.
DR   OMA; YQLFEFE; -.
DR   OrthoDB; 1828393at2; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0043158; P:heterocyst differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   PANTHER; PTHR11054; PTHR11054; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   2: Evidence at transcript level;
KW   Heterocyst; Hydrolase; Reference proteome.
FT   CHAIN           1..240
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000090087"
FT   CONFLICT        13..16
FT                   /note="ALIA -> RSI (in Ref. 1; AAA50355)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="N -> D (in Ref. 1; AAA50355)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        235..237
FT                   /note="GAE -> RRT (in Ref. 1; AAA50355)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  26183 MW;  69DA7B9A72729F96 CRC64;
     MKKTVEVLPD QTALIARSLD LILTKLDTAI KQQGRFTIAL SGGSTPKPLY EAIAAQKLPW
     DKIHVFWGDE RYVSPDHPDS NELMARTAWL DRVDIPAENI HAVPTLDNNP AVSAAKYEQH
     LQTFFNSAPG EFPALDVVLL GMGDDAHTAS LFPHTEALQV RDRLITVGNK DGNPRITFTY
     PFINAASSVI FVVAGANKRP ALAQVFAPSA DDLAYPSRFI QPQGELLWLL DAAAGAELSV