ID   MOES_LYTVA              Reviewed;         572 AA.
AC   P52962;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Moesin;
OS   Lytechinus variegatus (Green sea urchin) (Echinus variegatus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7654;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7738093; DOI=10.1242/jcs.108.1.161;
RA   Bachman E.S., McClay D.R.;
RT   "Characterization of moesin in the sea urchin Lytechinus variegatus:
RT   redistribution to the plasma membrane following fertilization is inhibited
RT   by cytochalasin B.";
RL   J. Cell Sci. 108:161-171(1995).
CC   -!- FUNCTION: Probably involved in connections of major cytoskeletal
CC       structures to the plasma membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm,
CC       cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
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DR   EMBL; U14180; AAC46514.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52962; -.
DR   SMR; P52962; -.
DR   PRIDE; P52962; -.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13194; FERM_C_ERM; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 6.10.360.10; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR011174; ERM.
DR   InterPro; IPR041789; ERM_FERM_C.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR008954; Moesin_tail_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23281; PTHR23281; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PIRSF; PIRSF002305; ERM; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF48678; SSF48678; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Membrane.
FT   CHAIN           1..572
FT                   /note="Moesin"
FT                   /id="PRO_0000219420"
FT   DOMAIN          1..294
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          444..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..502
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   572 AA;  67579 MW;  E1BA3F8E84B5E764 CRC64;
     MPRGVAVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EIWFFGLQYI DSKGLVTWLK
     LNKKVVAQDL RKDNPLQFKF RVKFYPEEVT EELIQEITQR LFFLQIKEGI LSDEVYCPPE
     TSVLLASYAA QAKYGPHSAS TKARLTEDTN ILPKRVIEQH KMTKEQWYER VSNWHQEHLS
     LSKEDAITEY MKIAQDLEMY GVNYFEIRNK KGTDLWLGVD ALGLNVYEKD DKLTPKIGFP
     WSEIRNISFN DKKFVIKPIE KKAPDFVFYA SRLRINKRIL ALCMGNHELY MRRRKPDTIE
     VQQMKAQAKE EKQAKKLERE QLAIEMKKRQ ETEEKYKRLQ QQIREKELAE EKNREDLKRW
     EEESRAMQEK LKQQQMESEE YQSKVAAMEM QMNEATLERE MTAQEKEEMR ARVEALAEEK
     ARLEQSREES LKESAEFAEK LRLSQERERE LQEAQEAAAA QHAAQLAAQR EAQQLIPKDE
     GEEDEQDHEL EVQQDDNDDL DDKESYLPDK HLLDKLQKLQ SELQAMKDES KGEDRYDKIH
     QENIRAGRDK YQTLRNIRSG NTRQRIDTFE NI