MOFA1_HUMAN
ID MOFA1_HUMAN Reviewed; 127 AA.
AC Q9Y605; B3KVT2; D3DVT3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=MORF4 family-associated protein 1;
DE AltName: Full=Protein PGR1;
DE AltName: Full=Protein associated with MRG of 14 kDa;
GN Name=MRFAP1 {ECO:0000312|EMBL:AAH22797.1};
GN Synonyms=PAM14 {ECO:0000303|PubMed:11500496},
GN PGR1 {ECO:0000312|EMBL:AAD38498.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAD38498.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=T-cell {ECO:0000312|EMBL:AAD38498.1};
RA Juwana J.P., Gerlach K., Wadle A., Pfreundschuh M., Renner C.;
RT "PGR1 is a novel T-cell activation protein.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAD38498.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4] {ECO:0000312|EMBL:AAD38498.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000312|EMBL:AAH22797.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin {ECO:0000312|EMBL:AAH22797.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000305}
RP INTERACTION WITH MORF4L1, AND SUBCELLULAR LOCATION.
RX PubMed=11500496; DOI=10.1074/jbc.m103435200;
RA Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N.,
RA Pereira-Smith O.M.;
RT "MRG15 activates the B-myb promoter through formation of a nuclear complex
RT with the retinoblastoma protein and the novel protein PAM14.";
RL J. Biol. Chem. 276:39171-39178(2001).
RN [7] {ECO:0000305}
RP IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, AND SUBCELLULAR LOCATION.
RX PubMed=12397079; DOI=10.1074/jbc.m203839200;
RA Pardo P.S., Leung J.K., Lucchesi J.C., Pereira-Smith O.M.;
RT "MRG15, a novel chromodomain protein, is present in two distinct
RT multiprotein complexes involved in transcriptional activation.";
RL J. Biol. Chem. 277:50860-50866(2002).
RN [8] {ECO:0000305}
RP INTERACTION WITH MORF4L2.
RX PubMed=14506250; DOI=10.1074/jbc.m309192200;
RA Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R.,
RA Pereira-Smith O.M.;
RT "MRGX is a novel transcriptional regulator that exhibits activation or
RT repression of the B-myb promoter in a cell type-dependent manner.";
RL J. Biol. Chem. 278:49618-49624(2003).
RN [9] {ECO:0000305}
RP INTERACTION WITH MORF4L1.
RX PubMed=17008723; DOI=10.1110/ps.062397806;
RA Zhang P., Zhao J., Wang B., Du J., Lu Y., Chen J., Ding J.;
RT "The MRG domain of human MRG15 uses a shallow hydrophobic pocket to
RT interact with the N-terminal region of PAM14.";
RL Protein Sci. 15:2423-2434(2006).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Found in a complex composed of MORF4L1, MRFAP1 and RB1.
CC Interacts via its N-terminus with MORF4L1. Interacts with CSTB and
CC MORF4L2. {ECO:0000250|UniProtKB:Q5M820, ECO:0000269|PubMed:11500496,
CC ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:14506250,
CC ECO:0000269|PubMed:17008723}.
CC -!- INTERACTION:
CC Q9Y605; P01023: A2M; NbExp=3; IntAct=EBI-995714, EBI-640741;
CC Q9Y605; Q9NYB9-2: ABI2; NbExp=5; IntAct=EBI-995714, EBI-11096309;
CC Q9Y605; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-995714, EBI-742038;
CC Q9Y605; Q92870-2: APBB2; NbExp=3; IntAct=EBI-995714, EBI-21535880;
CC Q9Y605; P54253: ATXN1; NbExp=6; IntAct=EBI-995714, EBI-930964;
CC Q9Y605; Q8WUW1: BRK1; NbExp=6; IntAct=EBI-995714, EBI-2837444;
CC Q9Y605; Q9H972: C14orf93; NbExp=3; IntAct=EBI-995714, EBI-10329620;
CC Q9Y605; Q6ZUJ4: C3orf62; NbExp=3; IntAct=EBI-995714, EBI-2837036;
CC Q9Y605; Q969G5: CAVIN3; NbExp=5; IntAct=EBI-995714, EBI-3893101;
CC Q9Y605; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-995714, EBI-10749669;
CC Q9Y605; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-995714, EBI-10303987;
CC Q9Y605; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-995714, EBI-12593112;
CC Q9Y605; P50570-2: DNM2; NbExp=3; IntAct=EBI-995714, EBI-10968534;
CC Q9Y605; Q9C005: DPY30; NbExp=3; IntAct=EBI-995714, EBI-744973;
CC Q9Y605; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-995714, EBI-11958845;
CC Q9Y605; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-995714, EBI-11110431;
CC Q9Y605; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-995714, EBI-10181260;
CC Q9Y605; P01112: HRAS; NbExp=3; IntAct=EBI-995714, EBI-350145;
CC Q9Y605; P42858: HTT; NbExp=19; IntAct=EBI-995714, EBI-466029;
CC Q9Y605; O60333-2: KIF1B; NbExp=3; IntAct=EBI-995714, EBI-10975473;
CC Q9Y605; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-995714, EBI-14069005;
CC Q9Y605; O14901: KLF11; NbExp=3; IntAct=EBI-995714, EBI-948266;
CC Q9Y605; Q9UBU8: MORF4L1; NbExp=7; IntAct=EBI-995714, EBI-399246;
CC Q9Y605; Q9UBU8-2: MORF4L1; NbExp=15; IntAct=EBI-995714, EBI-10288852;
CC Q9Y605; Q15014: MORF4L2; NbExp=16; IntAct=EBI-995714, EBI-399257;
CC Q9Y605; Q96HT8: MRFAP1L1; NbExp=6; IntAct=EBI-995714, EBI-748896;
CC Q9Y605; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-995714, EBI-3923617;
CC Q9Y605; Q9H0N5: PCBD2; NbExp=3; IntAct=EBI-995714, EBI-634289;
CC Q9Y605; Q96NZ9: PRAP1; NbExp=3; IntAct=EBI-995714, EBI-2116102;
CC Q9Y605; P54646: PRKAA2; NbExp=3; IntAct=EBI-995714, EBI-1383852;
CC Q9Y605; P60891: PRPS1; NbExp=3; IntAct=EBI-995714, EBI-749195;
CC Q9Y605; P49768-2: PSEN1; NbExp=3; IntAct=EBI-995714, EBI-11047108;
CC Q9Y605; O00560: SDCBP; NbExp=3; IntAct=EBI-995714, EBI-727004;
CC Q9Y605; Q9H788: SH2D4A; NbExp=5; IntAct=EBI-995714, EBI-747035;
CC Q9Y605; Q2TAY7: SMU1; NbExp=5; IntAct=EBI-995714, EBI-298027;
CC Q9Y605; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-995714, EBI-5235340;
CC Q9Y605; Q9H5I1: SUV39H2; NbExp=2; IntAct=EBI-995714, EBI-723127;
CC Q9Y605; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-995714, EBI-11523345;
CC Q9Y605; O14656-2: TOR1A; NbExp=3; IntAct=EBI-995714, EBI-25847109;
CC Q9Y605; P07951-2: TPM2; NbExp=3; IntAct=EBI-995714, EBI-10977815;
CC Q9Y605; Q96LD4-2: TRIM47; NbExp=3; IntAct=EBI-995714, EBI-12371725;
CC Q9Y605; Q86WV8: TSC1; NbExp=3; IntAct=EBI-995714, EBI-12806590;
CC Q9Y605; P10599: TXN; NbExp=3; IntAct=EBI-995714, EBI-594644;
CC Q9Y605; Q99757: TXN2; NbExp=3; IntAct=EBI-995714, EBI-2932492;
CC Q9Y605; Q9HAC8: UBTD1; NbExp=5; IntAct=EBI-995714, EBI-745871;
CC Q9Y605; Q9BRT2: UQCC2; NbExp=3; IntAct=EBI-995714, EBI-1054584;
CC Q9Y605; O76024: WFS1; NbExp=3; IntAct=EBI-995714, EBI-720609;
CC Q9Y605; Q8N720: ZNF655; NbExp=3; IntAct=EBI-995714, EBI-625509;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11500496,
CC ECO:0000269|PubMed:12397079}. Cytoplasm, perinuclear region
CC {ECO:0000269|PubMed:11500496, ECO:0000269|PubMed:12397079}.
CC Note=Colocalizes with MORF4L1 to cell nuclei.
CC {ECO:0000269|PubMed:11500496, ECO:0000269|PubMed:12397079}.
CC -!- SIMILARITY: Belongs to the MORF4 family-associated protein family.
CC {ECO:0000305}.
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DR EMBL; AF116272; AAD38498.1; -; Genomic_DNA.
DR EMBL; CR457144; CAG33425.1; -; mRNA.
DR EMBL; AK123360; BAG53894.1; -; mRNA.
DR EMBL; CH471131; EAW82386.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82387.1; -; Genomic_DNA.
DR EMBL; BC022797; AAH22797.1; -; mRNA.
DR CCDS; CCDS3389.1; -.
DR RefSeq; NP_001258982.1; NM_001272053.1.
DR RefSeq; NP_150638.1; NM_033296.2.
DR AlphaFoldDB; Q9Y605; -.
DR SMR; Q9Y605; -.
DR BioGRID; 125039; 101.
DR CORUM; Q9Y605; -.
DR IntAct; Q9Y605; 62.
DR MINT; Q9Y605; -.
DR STRING; 9606.ENSP00000318352; -.
DR iPTMnet; Q9Y605; -.
DR PhosphoSitePlus; Q9Y605; -.
DR SwissPalm; Q9Y605; -.
DR BioMuta; MRFAP1; -.
DR DMDM; 74735297; -.
DR EPD; Q9Y605; -.
DR jPOST; Q9Y605; -.
DR MassIVE; Q9Y605; -.
DR MaxQB; Q9Y605; -.
DR PaxDb; Q9Y605; -.
DR PeptideAtlas; Q9Y605; -.
DR PRIDE; Q9Y605; -.
DR ProteomicsDB; 86568; -.
DR Antibodypedia; 43334; 101 antibodies from 20 providers.
DR DNASU; 93621; -.
DR Ensembl; ENST00000320912.8; ENSP00000318352.4; ENSG00000179010.16.
DR Ensembl; ENST00000382581.5; ENSP00000372024.4; ENSG00000179010.16.
DR Ensembl; ENST00000507420.1; ENSP00000422065.1; ENSG00000179010.16.
DR GeneID; 93621; -.
DR KEGG; hsa:93621; -.
DR MANE-Select; ENST00000382581.5; ENSP00000372024.4; NM_033296.3; NP_150638.1.
DR UCSC; uc003gjg.3; human.
DR CTD; 93621; -.
DR DisGeNET; 93621; -.
DR GeneCards; MRFAP1; -.
DR HGNC; HGNC:24549; MRFAP1.
DR HPA; ENSG00000179010; Low tissue specificity.
DR MIM; 616905; gene.
DR neXtProt; NX_Q9Y605; -.
DR OpenTargets; ENSG00000179010; -.
DR PharmGKB; PA142671332; -.
DR VEuPathDB; HostDB:ENSG00000179010; -.
DR eggNOG; ENOG502RU25; Eukaryota.
DR GeneTree; ENSGT00940000155541; -.
DR HOGENOM; CLU_166966_1_0_1; -.
DR InParanoid; Q9Y605; -.
DR OMA; GRATKRC; -.
DR OrthoDB; 1557272at2759; -.
DR PhylomeDB; Q9Y605; -.
DR TreeFam; TF338232; -.
DR PathwayCommons; Q9Y605; -.
DR SignaLink; Q9Y605; -.
DR BioGRID-ORCS; 93621; 19 hits in 1078 CRISPR screens.
DR ChiTaRS; MRFAP1; human.
DR GeneWiki; MRFAP1; -.
DR GenomeRNAi; 93621; -.
DR Pharos; Q9Y605; Tbio.
DR PRO; PR:Q9Y605; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9Y605; protein.
DR Bgee; ENSG00000179010; Expressed in endothelial cell and 193 other tissues.
DR ExpressionAtlas; Q9Y605; baseline and differential.
DR Genevisible; Q9Y605; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR029254; MRFAP1.
DR PANTHER; PTHR31324; PTHR31324; 1.
DR Pfam; PF15155; MRFAP1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..127
FT /note="MORF4 family-associated protein 1"
FT /id="PRO_0000306176"
FT COILED 92..126
FT /evidence="ECO:0000255"
SQ SEQUENCE 127 AA; 14650 MW; 11B115C2CCD661C8 CRC64;
MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY LRNRSKLWEM
DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA EEKAKEIAKM AEMLVELVRR
IEKSESS
