MOFA1_MOUSE
ID MOFA1_MOUSE Reviewed; 125 AA.
AC Q9CQL7; Q9CX68;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=MORF4 family-associated protein 1;
DE AltName: Full=Protein associated with MRG of 14 kDa;
GN Name=Mrfap1 {ECO:0000312|MGI:MGI:1914818}; Synonyms=Pam14;
GN ORFNames=MNCb-1039;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB93545.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB93545.1};
RC TISSUE=Brain {ECO:0000312|EMBL:BAB93545.1};
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAB26527.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB26527.1}, and
RC NOD {ECO:0000312|EMBL:BAE42029.1};
RC TISSUE=Blastocyst {ECO:0000312|EMBL:BAE39260.1},
RC Cecum {ECO:0000312|EMBL:BAB31337.1},
RC Dendritic cell {ECO:0000312|EMBL:BAE42029.1},
RC Embryo {ECO:0000312|EMBL:BAB30963.1},
RC Embryonic testis {ECO:0000312|EMBL:BAB31978.1}, and
RC Tongue {ECO:0000312|EMBL:BAB26527.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAH10209.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH10209.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, TISSUE SPECIFICITY, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=15367658; DOI=10.1128/mcb.24.19.8366-8373.2004;
RA Tominaga K., Magee D.M., Matzuk M.M., Pereira-Smith O.M.;
RT "PAM14, a novel MRG- and Rb-associated protein, is not required for
RT development and T-cell function in mice.";
RL Mol. Cell. Biol. 24:8366-8373(2004).
CC -!- SUBUNIT: Found in a complex composed of MORF4L1, MRFAP1 and RB1.
CC Interacts via its N-terminus with MORF4L1. Interacts with CSTB and
CC MORF4L2. {ECO:0000250|UniProtKB:Q5M820, ECO:0000250|UniProtKB:Q9Y605,
CC ECO:0000269|PubMed:15367658}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y605}.
CC Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Y605}.
CC Note=Colocalizes with MORF4L1 to cell nuclei.
CC {ECO:0000250|UniProtKB:Q9Y605}.
CC -!- TISSUE SPECIFICITY: Widely expressed in all tissues examined and as
CC early as 7 days during embryonic development.
CC {ECO:0000269|PubMed:15367658}.
CC -!- DISRUPTION PHENOTYPE: Male mice are viable, fertile and show normal T-
CC cell function. {ECO:0000269|PubMed:15367658}.
CC -!- SIMILARITY: Belongs to the MORF4 family-associated protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31978.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB041651; BAB93545.1; -; mRNA.
DR EMBL; AK009827; BAB26527.1; -; mRNA.
DR EMBL; AK017832; BAB30963.1; -; mRNA.
DR EMBL; AK018675; BAB31337.1; -; mRNA.
DR EMBL; AK020049; BAB31978.1; ALT_FRAME; mRNA.
DR EMBL; AK159464; BAE35105.1; -; mRNA.
DR EMBL; AK167112; BAE39260.1; -; mRNA.
DR EMBL; AK170789; BAE42029.1; -; mRNA.
DR EMBL; AK170909; BAE42107.1; -; mRNA.
DR EMBL; AK170984; BAE42158.1; -; mRNA.
DR EMBL; BC010209; AAH10209.1; -; mRNA.
DR CCDS; CCDS19242.1; -.
DR RefSeq; NP_080518.1; NM_026242.3.
DR AlphaFoldDB; Q9CQL7; -.
DR SMR; Q9CQL7; -.
DR BioGRID; 212280; 4.
DR IntAct; Q9CQL7; 1.
DR STRING; 10090.ENSMUSP00000067135; -.
DR iPTMnet; Q9CQL7; -.
DR PhosphoSitePlus; Q9CQL7; -.
DR EPD; Q9CQL7; -.
DR MaxQB; Q9CQL7; -.
DR PaxDb; Q9CQL7; -.
DR PRIDE; Q9CQL7; -.
DR DNASU; 67568; -.
DR Ensembl; ENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
DR GeneID; 67568; -.
DR KEGG; mmu:67568; -.
DR UCSC; uc008xfa.2; mouse.
DR CTD; 93621; -.
DR MGI; MGI:1914818; Mrfap1.
DR VEuPathDB; HostDB:ENSMUSG00000055302; -.
DR eggNOG; ENOG502RU25; Eukaryota.
DR GeneTree; ENSGT00940000155541; -.
DR HOGENOM; CLU_166966_1_0_1; -.
DR InParanoid; Q9CQL7; -.
DR OMA; GRATKRC; -.
DR OrthoDB; 1557272at2759; -.
DR PhylomeDB; Q9CQL7; -.
DR TreeFam; TF338232; -.
DR BioGRID-ORCS; 67568; 1 hit in 66 CRISPR screens.
DR ChiTaRS; Mrfap1; mouse.
DR PRO; PR:Q9CQL7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CQL7; protein.
DR Bgee; ENSMUSG00000055302; Expressed in ectoplacental cone and 59 other tissues.
DR Genevisible; Q9CQL7; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR029254; MRFAP1.
DR PANTHER; PTHR31324; PTHR31324; 1.
DR Pfam; PF15155; MRFAP1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..125
FT /note="MORF4 family-associated protein 1"
FT /id="PRO_0000306177"
FT REGION 75..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 94..124
FT /evidence="ECO:0000255"
SQ SEQUENCE 125 AA; 14194 MW; 7933E2FBCDAFF90E CRC64;
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP ARNRGKLWEM
DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE KAQEMAKMAE MLVQLVRRIE
KSESS
