ID   MOFA1_RAT               Reviewed;         125 AA.
AC   Q5M820; Q8K3W6;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=MORF4 family-associated protein 1;
DE   AltName: Full=T-cell activation protein-related protein;
GN   Name=Mrfap1 {ECO:0000312|RGD:628631};
GN   Synonyms=Pgr1 {ECO:0000312|RGD:628631};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAN03958.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND INTERACTION WITH CSTB.
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAN03958.1};
RC   TISSUE=Cerebellum {ECO:0000312|EMBL:AAN03958.1};
RX   PubMed=12393805; DOI=10.1093/hmg/11.23.2941;
RA   Di Giaimo R., Riccio M., Santi S., Galeotti C., Ambrosetti D.C., Melli M.;
RT   "New insights into the molecular basis of progressive myoclonus epilepsy: a
RT   multiprotein complex with cystatin B.";
RL   Hum. Mol. Genet. 11:2941-2950(2002).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAH88308.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Liver {ECO:0000312|EMBL:AAH88308.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Found in a complex composed of MORF4L1, MRFAP1 and RB1.
CC       Interacts via its N-terminus with MORF4L1. Interacts with CSTB and
CC       MORF4L2. {ECO:0000250|UniProtKB:Q9Y605, ECO:0000269|PubMed:12393805}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y605}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Y605}.
CC       Note=Colocalizes with MORF4L1 to cell nuclei.
CC       {ECO:0000250|UniProtKB:Q9Y605}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|PubMed:15489334};
CC         IsoId=Q5M820-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:12393805};
CC         IsoId=Q5M820-2; Sequence=VSP_052549;
CC   -!- SIMILARITY: Belongs to the MORF4 family-associated protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN03958.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF526268; AAN03958.1; ALT_INIT; mRNA.
DR   EMBL; BC088308; AAH88308.1; -; mRNA.
DR   RefSeq; NP_001009264.1; NM_001009264.1. [Q5M820-1]
DR   AlphaFoldDB; Q5M820; -.
DR   SMR; Q5M820; -.
DR   STRING; 10116.ENSRNOP00000008121; -.
DR   PhosphoSitePlus; Q5M820; -.
DR   jPOST; Q5M820; -.
DR   PaxDb; Q5M820; -.
DR   GeneID; 282585; -.
DR   KEGG; rno:282585; -.
DR   CTD; 93621; -.
DR   RGD; 628631; Mrfap1.
DR   VEuPathDB; HostDB:ENSRNOG00000056162; -.
DR   eggNOG; ENOG502RU25; Eukaryota.
DR   HOGENOM; CLU_166966_1_0_1; -.
DR   InParanoid; Q5M820; -.
DR   OrthoDB; 1557272at2759; -.
DR   PRO; PR:Q5M820; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000055319; Expressed in cerebellum and 19 other tissues.
DR   Genevisible; Q5M820; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029254; MRFAP1.
DR   PANTHER; PTHR31324; PTHR31324; 1.
DR   Pfam; PF15155; MRFAP1; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..125
FT                   /note="MORF4 family-associated protein 1"
FT                   /id="PRO_0000306179"
FT   REGION          76..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          94..124
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         18..41
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12393805"
FT                   /id="VSP_052549"
SQ   SEQUENCE   125 AA;  14222 MW;  7933F06246BD6085 CRC64;
     MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP VRNRGKLWEM
     DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE KAQEMAKMAE MLVQLVRRIE
     KSESS