ID   MOG1_BOVIN              Reviewed;         186 AA.
AC   Q32PE2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Ran guanine nucleotide release factor;
DE            Short=RanGNRF;
DE   AltName: Full=Ran-binding protein MOG1;
GN   Name=RANGRF; Synonyms=MOG1, RANGNRF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate the intracellular trafficking of RAN. Promotes
CC       guanine nucleotide release from RAN and inhibits binding of new GTP by
CC       preventing the binding of the RAN guanine nucleotide exchange factor
CC       RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby
CC       plays a role in the regulation of RAN-dependent mitotic spindle
CC       dynamics. Enhances the expression of SCN5A at the cell membrane in
CC       cardiomyocytes. {ECO:0000250|UniProtKB:Q9HD47}.
CC   -!- SUBUNIT: Monomer. Interacts with RAN, both RAN-GTP and RAN-GDP.
CC       Competes with RCC1 for a common binding site on RAN and thereby
CC       inhibits RCC1-mediated nucleotide exchange (By similarity). Forms a
CC       complex with RAN-GTP and RANBP1 (By similarity). Interacts with the
CC       cytoplasmic loop 2 of SCN5A (By similarity).
CC       {ECO:0000250|UniProtKB:Q9HD47, ECO:0000250|UniProtKB:Q9JIB0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HD47}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9HD47}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9HD47}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9HD47}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9HD47}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9HD47}. Note=May shuttle between the nucleus
CC       and cytoplasm. {ECO:0000250|UniProtKB:Q9HD47}.
CC   -!- SIMILARITY: Belongs to the MOG1 family. {ECO:0000305}.
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DR   EMBL; BC108151; AAI08152.1; -; mRNA.
DR   RefSeq; NP_001032537.1; NM_001037460.2.
DR   AlphaFoldDB; Q32PE2; -.
DR   SMR; Q32PE2; -.
DR   STRING; 9913.ENSBTAP00000025038; -.
DR   PaxDb; Q32PE2; -.
DR   GeneID; 512506; -.
DR   KEGG; bta:512506; -.
DR   CTD; 29098; -.
DR   eggNOG; KOG3329; Eukaryota.
DR   InParanoid; Q32PE2; -.
DR   OrthoDB; 1579830at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00224; Mog1; 1.
DR   InterPro; IPR007681; Mog1.
DR   InterPro; IPR016123; Mog1/PsbP_a/b/a-sand.
DR   PANTHER; PTHR15837; PTHR15837; 1.
DR   Pfam; PF04603; Mog1; 1.
DR   SUPFAM; SSF55724; SSF55724; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..186
FT                   /note="Ran guanine nucleotide release factor"
FT                   /id="PRO_0000330635"
FT   REGION          27..70
FT                   /note="Interaction with RAN"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HD47"
SQ   SEQUENCE   186 AA;  20680 MW;  97E9B2D510666985 CRC64;
     MEPTRDNPLF GGAFSATLPP GAIDVSDLRP VPDHQEVFCH RVTDQSLIVE LLELQAHVQG
     EEAARYHFED VGGVQEARAV QVETVQPLVL EKLALRGCCQ EAWILSGQQQ VAKENQQVAK
     YVTLHQALLR LPQYQTDLLL TFNQPPPENR SSLGPENLSI PPWSLGDFEQ LVTSLTLHDP
     NIFGPE