MOG1_CAEEL
ID MOG1_CAEEL Reviewed; 1131 AA.
AC P34498;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1;
DE EC=3.6.4.13;
DE AltName: Full=Masculinization of germline protein 1;
DE AltName: Full=Sex determination protein mog-1;
GN Name=mog-1; ORFNames=K03H1.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2;
RX PubMed=10022905; DOI=10.1128/mcb.19.3.2189;
RA Puoti A., Kimble J.;
RT "The Caenorhabditis elegans sex determination gene mog-1 encodes a member
RT of the DEAH-Box protein family.";
RL Mol. Cell. Biol. 19:2189-2197(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable ATP-binding RNA helicase involved in pre-mRNA
CC splicing.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- INTERACTION:
CC P34498; Q21502: mep-1; NbExp=3; IntAct=EBI-3651301, EBI-319858;
CC P34498; O45244: mog-4; NbExp=2; IntAct=EBI-3651301, EBI-326143;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000305}.
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DR EMBL; AF120269; AAD13795.1; -; mRNA.
DR EMBL; Z29560; CAA82662.1; -; Genomic_DNA.
DR PIR; F88570; F88570.
DR PIR; S41025; S41025.
DR RefSeq; NP_499212.1; NM_066811.6.
DR AlphaFoldDB; P34498; -.
DR SMR; P34498; -.
DR BioGRID; 41603; 11.
DR IntAct; P34498; 4.
DR STRING; 6239.K03H1.2; -.
DR iPTMnet; P34498; -.
DR EPD; P34498; -.
DR PaxDb; P34498; -.
DR PeptideAtlas; P34498; -.
DR PRIDE; P34498; -.
DR EnsemblMetazoa; K03H1.2.1; K03H1.2.1; WBGene00003389.
DR GeneID; 176409; -.
DR KEGG; cel:CELE_K03H1.2; -.
DR UCSC; K03H1.2.1; c. elegans.
DR CTD; 176409; -.
DR WormBase; K03H1.2; CE01027; WBGene00003389; mog-1.
DR eggNOG; KOG0924; Eukaryota.
DR GeneTree; ENSGT00940000156898; -.
DR HOGENOM; CLU_001832_6_2_1; -.
DR InParanoid; P34498; -.
DR OMA; VMFHRSP; -.
DR OrthoDB; 354219at2759; -.
DR PhylomeDB; P34498; -.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72187; mRNA 3'-end processing.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR PRO; PR:P34498; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003389; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0040022; P:feminization of hermaphroditic germ-line; IMP:WormBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF04408; HA2; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Developmental protein; Helicase; Hydrolase; mRNA processing;
KW mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..1131
FT /note="Probable pre-mRNA-splicing factor ATP-dependent RNA
FT helicase mog-1"
FT /id="PRO_0000055148"
FT DOMAIN 451..614
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 629..812
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 1..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 561..564
FT /note="DEAH box"
FT COMPBIAS 46..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 464..471
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1131 AA; 129424 MW; 258C85D6584FAF3A CRC64;
MSDKRADGRL EGTSDTFGGL VIKKKKVEGD SKPTEPSGKS LLGLDRLAST KREHARKRLE
DDDDRGVTES VRKGIEKVHE KHRDRDDRGM KYKSRDDDRR RDRDRSERRE PSSRRGWKDR
SGDQTPRFKV PDTPSRMSWD QDDREGSSRK RNSWDMPTPR GERDRKRYMD SERSISSAWR
SERRNRDDEK RRRHRKPEDS VRSVKEEKAE PTFHDDEERA QWEEEQKNLD REWYDNEGAF
DDEYNPFNKV SDEFVEKREK QWQEKTQKPR LTVKQQAIKR ENELWENNRL HRSGVVAMAD
ELSSIFEDET DENRVTILVQ NIVPPFLDGR IVFTKQAQPI IPVVDTTCDM AVSAARGSVA
VRKRREVEDR KKAQDKHWEL AGSKLGNLMG VKEKKDETAD PEDDDSGNYK ESHQFASHMK
DNEAVSDFAM EKSIKQQREY LPVFACRQKM MNVIRENNVV IIVGETGSGK TTQLAQYLLE
DGFGDSGLIG CTQPRRVAAM SVARRVADEM GVDLGQDVGY AIRFEDCTSE KTIIKYMTDG
ILLRECLGDG SLDQYSAIIM DEAHERSLNT DVLFGLLREV IAKRADLKLI VTSATMDADK
FADFFGGNCP TFTIPGRTFP VELFHARTPV EDYVDAAVKQ AVTIHLGGMD GDILIFMPGQ
EDIECTCEMI KEKLGELDEA PPLAVLPIYS QLPSDLQAKI FQRAPGGMRK AIVATNIAET
SLTVDGILFV IDPGFCKMKV YNPRIGMDAL SIFPVSQASA NQRTGRAGRT GPGQCYRLYT
ERQFKDELLK STVPEIQRTN LANVVLLLKS LGVDDLLKFH FMDAPPQDNM LNSMYQLWTL
GALDNTGQLT PMGRKMVEFP LDPTLSKMLI MSAEMGCSDE VLTIVSMLSV PAIFFRPKGR
EEEADAKKEK FQVPESDHLT FLNVYIQWRT HKYSAKWCAD NYLHVKALKK VREVRAQLKE
IMQDLKLPLI SNGSEWDIVR KCICSAYFHN AARLKGIGEY VNVRTGIPCF LHPTSALFGM
GFMPDYVVYH ELIMTAKEYM QCVTAVDAIW LAELGPMFYS IKESKQSRKE LKMESVRTVE
TMEAEMREAQ KEMERRKEES DKAFKRPESS RRVVEVGSKS ARSERRKLWG L
