ID   MOG1_DANRE              Reviewed;         183 AA.
AC   A3KPP3; A7E2J7;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Ran guanine nucleotide release factor {ECO:0000312|Ensembl:ENSDARP00000137644};
DE            Short=RanGNRF;
DE   AltName: Full=Ran-binding protein MOG1;
GN   Name=rangrf {ECO:0000312|Ensembl:ENSDARP00000137644,
GN   ECO:0000312|ZFIN:ZDB-GENE-060526-143};
GN   Synonyms=mog1 {ECO:0000303|PubMed:26903377};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000312|EMBL:AAI50379.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin {ECO:0000312|EMBL:AAI50379.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX   PubMed=26903377; DOI=10.1038/srep21538;
RA   Zhou J., Wang L., Zuo M., Wang X., Ahmed A.S., Chen Q., Wang Q.K.;
RT   "Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and
RT   rhythm.";
RL   Sci. Rep. 6:21538-21538(2016).
CC   -!- FUNCTION: May regulate the intracellular trafficking of RAN. Promotes
CC       guanine nucleotide release from RAN and inhibits binding of new GTP.
CC       Plays a role in the regulation of the levels of GTP-bound RAN in the
CC       nucleus (By similarity). Required for normal expression of the ion
CC       channel hcn4 and for normal expression of the cardiac transcription
CC       factors nkx2.5, gata4 and hand2 during embryonic development. Required
CC       for normal embryonic heart development and normal heart rate
CC       (PubMed:26903377). {ECO:0000250|UniProtKB:Q9HD47,
CC       ECO:0000269|PubMed:26903377}.
CC   -!- SUBUNIT: Monomer. Interacts with ran (By similarity).
CC       {ECO:0000250|UniProtKB:Q9HD47}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HD47}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9HD47}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9HD47}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9HD47}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9HD47}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9HD47}. Note=May shuttle between the nucleus
CC       and cytoplasm. {ECO:0000250|UniProtKB:Q9HD47}.
CC   -!- DEVELOPMENTAL STAGE: Detected in one-cell-stage embryos, suggesting
CC       maternal expression. Detected in blastomeres at 2.5 to 4 hpf.
CC       Ubiquitous in embryos from 6 to 12 hpf. At 24 hpf, expression is
CC       ubiquitous, with higher levels of expression in the region of the brain
CC       and eyes. At 48 hpf, predominantly expressed in the brain area, but
CC       also detected in heart and fins. {ECO:0000269|PubMed:26903377}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes
CC       bradycardia and weakened myocardial contraction. Expression of hcn4 is
CC       decreased, and this may be the cause for the decreased heart rate.
CC       Morpholino knockdown causes defects in heart looping during embryonic
CC       heart development, probably due to the decreased expression of cardiac
CC       transcription factors in the anterior lateral mesoderm.
CC       {ECO:0000269|PubMed:26903377}.
CC   -!- SIMILARITY: Belongs to the MOG1 family. {ECO:0000305}.
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DR   EMBL; BX276102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR749165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150378; AAI50379.1; -; mRNA.
DR   RefSeq; NP_001093465.1; NM_001099995.1.
DR   RefSeq; XP_005165551.1; XM_005165494.3.
DR   RefSeq; XP_005165552.1; XM_005165495.2.
DR   RefSeq; XP_009300097.1; XM_009301822.2.
DR   AlphaFoldDB; A3KPP3; -.
DR   SMR; A3KPP3; -.
DR   STRING; 7955.ENSDARP00000105301; -.
DR   PaxDb; A3KPP3; -.
DR   Ensembl; ENSDART00000166050; ENSDARP00000137010; ENSDARG00000098786.
DR   Ensembl; ENSDART00000170218; ENSDARP00000137644; ENSDARG00000098786.
DR   GeneID; 559102; -.
DR   KEGG; dre:559102; -.
DR   CTD; 29098; -.
DR   ZFIN; ZDB-GENE-060526-143; rangrf.
DR   eggNOG; KOG3329; Eukaryota.
DR   GeneTree; ENSGT00390000013834; -.
DR   HOGENOM; CLU_081345_2_1_1; -.
DR   InParanoid; A3KPP3; -.
DR   OMA; QCVSKFN; -.
DR   OrthoDB; 1579830at2759; -.
DR   PhylomeDB; A3KPP3; -.
DR   TreeFam; TF332074; -.
DR   Reactome; R-DRE-5576892; Phase 0 - rapid depolarisation.
DR   PRO; PR:A3KPP3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000098786; Expressed in early embryo and 30 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR   GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0060047; P:heart contraction; IMP:ZFIN.
DR   GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0003254; P:regulation of membrane depolarization; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR007681; Mog1.
DR   InterPro; IPR016123; Mog1/PsbP_a/b/a-sand.
DR   PANTHER; PTHR15837; PTHR15837; 1.
DR   Pfam; PF04603; Mog1; 1.
DR   SUPFAM; SSF55724; SSF55724; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..183
FT                   /note="Ran guanine nucleotide release factor"
FT                   /id="PRO_0000442921"
FT   REGION          23..66
FT                   /note="Interaction with RAN"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HD47"
FT   CONFLICT        168
FT                   /note="Q -> R (in Ref. 2; AAI50379)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   183 AA;  20301 MW;  951861320049D19A CRC64;
     MSRPLFGGAL SAVFPSSVMD ISELRQIPDN QEVFAHSQTD QSIIIELLEY QSQVQDADAA
     RYHFEDVAGS NKAIENGTWE VRVVEQVPQS EISMQECSSA WLLSGAQLVS KFNEEAKNTV
     NVHQCLFRLP QFTTDILMTF NDPVFINPLS SSAAGNMEAI PWTLQDFQGV LQSLRLLDSG
     VFG