ID   MOGR_LISM4              Reviewed;         306 AA.
AC   G2K449; Q8Y960;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Motility gene repressor MogR;
GN   Name=mogR; OrderedLocusNames=LMRG_00362;
OS   Listeria monocytogenes serotype 1/2a (strain 10403S).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=393133;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=10403S;
RX   PubMed=15302931; DOI=10.1073/pnas.0404924101;
RA   Gruendling A., Burrack L.S., Bouwer H.G.A., Higgins D.E.;
RT   "Listeria monocytogenes regulates flagellar motility gene expression
RT   through MogR, a transcriptional repressor required for virulence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12318-12323(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10403S;
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Borowsky M., Borodovsky M., Young S.K., Zeng Q., Koehrsen M.,
RA   Fitzgerald M., Wiedmann M., Swaminathan B., Lauer P., Portnoy D.,
RA   Cossart P., Buchrieser C., Higgins D., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Borenstein D., Brown A., Chapman S.B., Chen Z.,
RA   Dunbar C.D., Engels R., Freedman E., Gearin G., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L.,
RA   Lui A., MacDonald J., Mehta T., Montmayeur A., Neiman D., Park D.,
RA   Pearson M., Priest M., Richards J., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Listeria monocytogenes strain 10403S.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor of flagellar motility genes, such
CC       as flaA, during extracellular growth at 37 degrees Celsius and during
CC       intracellular infection. Binds directly to the gene promoter region and
CC       probably prevents RNA polymerase binding. At low temperatures, MogR
CC       repression activity is modulated by the DegU response regulator in an
CC       unknown mechanism. Required for full virulence.
CC       {ECO:0000269|PubMed:15302931}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15302931}.
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DR   EMBL; AY590468; AAT48711.1; -; Genomic_DNA.
DR   EMBL; CP002002; AEO05677.1; -; Genomic_DNA.
DR   RefSeq; WP_003721794.1; NC_017544.1.
DR   AlphaFoldDB; G2K449; -.
DR   SMR; G2K449; -.
DR   EnsemblBacteria; AEO05677; AEO05677; LMRG_00362.
DR   KEGG; lmt:LMRG_00362; -.
DR   HOGENOM; CLU_080650_0_0_9; -.
DR   OMA; VYQFCQR; -.
DR   Proteomes; UP000001288; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1030; -; 1.
DR   InterPro; IPR021009; MogR_DNA-bd.
DR   InterPro; IPR038245; MogR_DNA-bd_sf.
DR   Pfam; PF12181; MogR_DNAbind; 1.
PE   4: Predicted;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..306
FT                   /note="Motility gene repressor MogR"
FT                   /id="PRO_0000419031"
SQ   SEQUENCE   306 AA;  35254 MW;  4F74CAF0B9BE5D8E CRC64;
     MPKSEIRKLL QEIKKQVDNP GNSSTTEIKK MASEAGIDEQ TAEEIYHLLT EFYQAVEEHG
     GIEKYMHSNI SWLKIELELL SACYQIAILE DMKVLDISEM LSLNDLRIFP KTPSQLQNTY
     YKLKKELIQV EDIPKNKPGR KRKTQKNTKK EKTNIFGKVV PAEFKAPASI KEQISYDKSR
     EKNLVDLLSG VKSNVQLLSE NQGEENNVYD LLKSIYSLSS LAVQKEELDK KYQDLQTKCQ
     ELEQENSYLK QQNETMTDSF HTLVLQVADF AYASDLDQIQ ALPLFSQQLV VTLNQLGVFK
     ENYKQM