ID   MOGR_LISMF              Reviewed;         306 AA.
AC   Q722M0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Motility gene repressor MogR;
GN   Name=mogR; OrderedLocusNames=LMOf2365_0710;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA   Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA   White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA   Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA   Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA   Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA   Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT   pathogen Listeria monocytogenes reveal new insights into the core genome
RT   components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- FUNCTION: Transcriptional repressor of flagellar motility genes, such
CC       as flaA, during extracellular growth at 37 degrees Celsius and during
CC       intracellular infection. Binds directly to gene promoter region and
CC       probably prevents RNA polymerase binding. At low temperatures, MogR
CC       repression activity is modulated by the DegU response regulator in an
CC       unknown mechanism. Required for full virulence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AE017262; AAT03491.1; -; Genomic_DNA.
DR   RefSeq; WP_003724414.1; NC_002973.6.
DR   AlphaFoldDB; Q722M0; -.
DR   SMR; Q722M0; -.
DR   KEGG; lmf:LMOf2365_0710; -.
DR   HOGENOM; CLU_080650_0_0_9; -.
DR   OMA; VYQFCQR; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1030; -; 1.
DR   InterPro; IPR021009; MogR_DNA-bd.
DR   InterPro; IPR038245; MogR_DNA-bd_sf.
DR   Pfam; PF12181; MogR_DNAbind; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..306
FT                   /note="Motility gene repressor MogR"
FT                   /id="PRO_0000247905"
SQ   SEQUENCE   306 AA;  35284 MW;  0E7576A3A3BF51A6 CRC64;
     MPKSEIRKLL QEIKKQVDNP GNSSTTEIKK MASEAGIDEK TAEEIYHLLT EFYQAVEEHG
     GIEKYMHSNI SWLKIELELL SACYQIAILE DMKVLDISEM LSLNDLRIFP KTPSQLQNTY
     YKLKKELIQV EDIPKNKPGR KRKTQKNTKK EKTNIFGKVV PAEFKAPTSI KEQISYDKSR
     EKNLVDLLSG VKSNVQLLSE NQGEENNVYD LLKSIYSLSS LAVQKEELDK KYQDLQTKCQ
     ELEQENSYLK QQNETMTDSF HTLVLQVADF AYASDLDQIQ ALPLFSQQLV VTLNQLGVFK
     ENYKQM