ID   MOGR_LISMO              Reviewed;         306 AA.
AC   P0DJO8; Q8Y960;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Motility gene repressor MogR;
GN   Name=mogR; OrderedLocusNames=lmo0674;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=15302931; DOI=10.1073/pnas.0404924101;
RA   Gruendling A., Burrack L.S., Bouwer H.G.A., Higgins D.E.;
RT   "Listeria monocytogenes regulates flagellar motility gene expression
RT   through MogR, a transcriptional repressor required for virulence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12318-12323(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=16617375; DOI=10.1371/journal.ppat.0020030;
RA   Shen A., Higgins D.E.;
RT   "The MogR transcriptional repressor regulates nonhierarchal expression of
RT   flagellar motility genes and virulence in Listeria monocytogenes.";
RL   PLoS Pathog. 2:282-295(2006).
CC   -!- FUNCTION: Transcriptional repressor of flagellar motility genes, such
CC       as flaA, during extracellular growth at 37 degrees Celsius and during
CC       intracellular infection. Binds directly to the gene promoter region and
CC       probably prevents RNA polymerase binding. At low temperatures, MogR
CC       repression activity is modulated by the DegU response regulator in an
CC       unknown mechanism. Required for full virulence.
CC       {ECO:0000269|PubMed:15302931, ECO:0000269|PubMed:16617375}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15302931}.
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DR   EMBL; AL591976; CAC98752.1; -; Genomic_DNA.
DR   PIR; AB1159; AB1159.
DR   RefSeq; NP_464201.1; NC_003210.1.
DR   RefSeq; WP_003721794.1; NZ_CP023861.1.
DR   PDB; 3FDQ; X-ray; 1.75 A; A/B=1-162.
DR   PDBsum; 3FDQ; -.
DR   AlphaFoldDB; P0DJO8; -.
DR   SMR; P0DJO8; -.
DR   STRING; 169963.lmo0674; -.
DR   PaxDb; P0DJO8; -.
DR   EnsemblBacteria; CAC98752; CAC98752; CAC98752.
DR   GeneID; 985015; -.
DR   KEGG; lmo:lmo0674; -.
DR   PATRIC; fig|169963.11.peg.695; -.
DR   eggNOG; ENOG50340G0; Bacteria.
DR   HOGENOM; CLU_080650_0_0_9; -.
DR   OMA; VYQFCQR; -.
DR   BioCyc; LMON169963:LMO0674-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   CollecTF; EXPREG_000008d0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IMP:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:CollecTF.
DR   Gene3D; 1.20.120.1030; -; 1.
DR   InterPro; IPR021009; MogR_DNA-bd.
DR   InterPro; IPR038245; MogR_DNA-bd_sf.
DR   Pfam; PF12181; MogR_DNAbind; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..306
FT                   /note="Motility gene repressor MogR"
FT                   /id="PRO_0000247906"
FT   HELIX           6..18
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   HELIX           24..35
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   HELIX           39..58
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   HELIX           62..66
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   STRAND          68..72
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   HELIX           74..89
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   HELIX           94..101
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   TURN            103..106
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   STRAND          108..111
FT                   /evidence="ECO:0007829|PDB:3FDQ"
FT   HELIX           113..124
FT                   /evidence="ECO:0007829|PDB:3FDQ"
SQ   SEQUENCE   306 AA;  35254 MW;  4F74CAF0B9BE5D8E CRC64;
     MPKSEIRKLL QEIKKQVDNP GNSSTTEIKK MASEAGIDEQ TAEEIYHLLT EFYQAVEEHG
     GIEKYMHSNI SWLKIELELL SACYQIAILE DMKVLDISEM LSLNDLRIFP KTPSQLQNTY
     YKLKKELIQV EDIPKNKPGR KRKTQKNTKK EKTNIFGKVV PAEFKAPASI KEQISYDKSR
     EKNLVDLLSG VKSNVQLLSE NQGEENNVYD LLKSIYSLSS LAVQKEELDK KYQDLQTKCQ
     ELEQENSYLK QQNETMTDSF HTLVLQVADF AYASDLDQIQ ALPLFSQQLV VTLNQLGVFK
     ENYKQM