MOG_CALJA
ID MOG_CALJA Reviewed; 245 AA.
AC Q29ZQ1; Q29ZP8; Q29ZP9; Q29ZQ0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Myelin-oligodendrocyte glycoprotein;
DE Flags: Precursor;
GN Name=MOG;
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
RX PubMed=16903876; DOI=10.1111/j.1471-4159.2006.04053.x;
RA Delarasse C., Della Gaspera B., Lu C.W., Lachapelle F., Gelot A.,
RA Rodriguez D., Dautigny A., Genain C., Pham-Dinh D.;
RT "Complex alternative splicing of the myelin oligodendrocyte glycoprotein
RT gene is unique to human and non-human primates.";
RL J. Neurochem. 98:1707-1717(2006).
CC -!- FUNCTION: Minor component of the myelin sheath. May be involved in
CC completion and/or maintenance of the myelin sheath and in cell-cell
CC communication. Mediates homophilic cell-cell adhesion (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q29ZQ1-1; Sequence=Displayed;
CC Name=2; Synonyms=MOG alpha-4;
CC IsoId=Q29ZQ1-2; Sequence=VSP_022786;
CC Name=3; Synonyms=MOG alpha-7Cj;
CC IsoId=Q29ZQ1-3; Sequence=VSP_022789;
CC Name=4; Synonyms=MOG alpha-4Cj;
CC IsoId=Q29ZQ1-4; Sequence=VSP_022787, VSP_022788;
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC -!- CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with
CC oligodendrocyte-myelin glycoprotein (OMG). {ECO:0000305}.
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DR EMBL; AY566834; AAU09333.1; -; mRNA.
DR EMBL; AY566835; AAU09334.1; -; mRNA.
DR EMBL; AY566836; AAU09335.1; -; mRNA.
DR EMBL; AY566837; AAU09336.1; -; mRNA.
DR RefSeq; NP_001244171.1; NM_001257242.1. [Q29ZQ1-1]
DR RefSeq; NP_001244172.1; NM_001257243.1. [Q29ZQ1-2]
DR RefSeq; NP_001244173.1; NM_001257244.1.
DR AlphaFoldDB; Q29ZQ1; -.
DR SMR; Q29ZQ1; -.
DR STRING; 9483.ENSCJAP00000028006; -.
DR GeneID; 100400400; -.
DR KEGG; cjc:100400400; -.
DR CTD; 4340; -.
DR eggNOG; ENOG502SQC1; Eukaryota.
DR HOGENOM; CLU_013137_10_4_1; -.
DR InParanoid; Q29ZQ1; -.
DR OrthoDB; 1057931at2759; -.
DR Proteomes; UP000008225; Chromosome 4.
DR Bgee; ENSCJAG00000043626; Expressed in cerebellum and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR016663; Myelin-oligodendrocyte_glycop.
DR Pfam; PF07686; V-set; 1.
DR PIRSF; PIRSF016522; MOG; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell adhesion; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..245
FT /note="Myelin-oligodendrocyte glycoprotein"
FT /id="PRO_0000274528"
FT TOPO_DOM 28..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 29..143
FT /note="Ig-like V-type"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 51..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 28..143
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16903876"
FT /id="VSP_022786"
FT VAR_SEQ 28..47
FT /note="GQFRVIGPSHPIQALVGDAA -> EMARIKMESRHLNIGVEQSC (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:16903876"
FT /id="VSP_022787"
FT VAR_SEQ 48..245
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16903876"
FT /id="VSP_022788"
FT VAR_SEQ 139..176
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16903876"
FT /id="VSP_022789"
SQ SEQUENCE 245 AA; 27920 MW; 2E7B648605A79811 CRC64;
MASLSKPSLP SYLCFLLLLL HVSSSYGGQF RVIGPSHPIQ ALVGDAAELP CRISPGKNAT
GMEVGWYRSP FSRVVHLYRN GKDQDGEQAP EYRGRTELLK DDIGEGKVTL KIRNVRFPDE
GGFTCFFRDH SYQEEAAMQL KVEDPFYWVS PGVLVLLAVL PVLFLQITVG LVFLYLQHRL
RGKLRAEIEN LHRTFDPHFL RVPCWKITLF VIVPVLGPLV ALIICYNWLH RRLAGQFLEE
LRNPF
