MOIH1_CANPG
ID MOIH1_CANPG Reviewed; 78 AA.
AC P81034;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Mandibular organ-inhibiting hormone 1;
DE Short=MOIH-1;
OS Cancer pagurus (Rock crab).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Cancroidea; Cancridae; Cancer.
OX NCBI_TaxID=6755;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Sinus gland;
RX PubMed=8662685; DOI=10.1074/jbc.271.22.12749;
RA Wainwright G., Webster S.G., Wilkinson M.C., Chung J.S., Rees H.H.;
RT "Structure and significance of mandibular organ-inhibiting hormone in the
RT crab, Cancer pagurus. Involvement in multihormonal regulation of growth and
RT reproduction.";
RL J. Biol. Chem. 271:12749-12754(1996).
CC -!- FUNCTION: Represses the synthesis of methyl farnesoate, the precursor
CC of insect juvenile hormone III in the mandibular organ.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC eyestalks and transported to the sinus gland where it is stored and
CC released.
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305}.
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DR AlphaFoldDB; P81034; -.
DR SMR; P81034; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR InterPro; IPR001166; Hyperglycemic.
DR InterPro; IPR001262; Hyperglycemic2.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR PRINTS; PR00549; HYPRGLYCEMC2.
DR PRINTS; PR00550; HYPRGLYCEMIC.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hormone; Neuropeptide; Secreted.
FT CHAIN 1..78
FT /note="Mandibular organ-inhibiting hormone 1"
FT /id="PRO_0000209866"
FT DISULFID 7..44
FT /evidence="ECO:0000250"
FT DISULFID 24..40
FT /evidence="ECO:0000250"
FT DISULFID 27..53
FT /evidence="ECO:0000250"
SQ SEQUENCE 78 AA; 9241 MW; 8DB338A39058A62D CRC64;
RRINNDCQNF IGNRAMYEKV DWICKDCANI FRKDGLLNNC RSNCFYNTEF LWCIDATENT
RNKEQLEQWA AILGAGWN