ID   MOIH2_CANPG             Reviewed;          78 AA.
AC   P81035;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Mandibular organ-inhibiting hormone 2;
DE            Short=MOIH-2;
OS   Cancer pagurus (Rock crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Cancroidea; Cancridae; Cancer.
OX   NCBI_TaxID=6755;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Sinus gland;
RX   PubMed=8662685; DOI=10.1074/jbc.271.22.12749;
RA   Wainwright G., Webster S.G., Wilkinson M.C., Chung J.S., Rees H.H.;
RT   "Structure and significance of mandibular organ-inhibiting hormone in the
RT   crab, Cancer pagurus. Involvement in multihormonal regulation of growth and
RT   reproduction.";
RL   J. Biol. Chem. 271:12749-12754(1996).
CC   -!- FUNCTION: Represses the synthesis of methyl farnesoate, the precursor
CC       of insect juvenile hormone III in the mandibular organ.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where it is stored and
CC       released.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P81035; -.
DR   SMR; P81035; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Neuropeptide; Secreted.
FT   CHAIN           1..78
FT                   /note="Mandibular organ-inhibiting hormone 2"
FT                   /id="PRO_0000209867"
FT   DISULFID        7..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        24..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  9241 MW;  21D338A390459ADE CRC64;
     RRINNDCQNF IGNRAMYEKV DWICKDCANI FRQDGLLNNC RSNCFYNTEF LWCIDATENT
     RNKEQLEQWA AILGAGWN