MOIH_LIBEM
ID MOIH_LIBEM Reviewed; 137 AA.
AC P56688;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Mandibular organ-inhibiting hormone;
DE Short=MOIH;
DE Contains:
DE RecName: Full=MOIH precursor-related peptide;
DE Contains:
DE RecName: Full=Mandibular organ-inhibiting hormone;
DE Flags: Precursor;
OS Libinia emarginata (Portly spider crab).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Majoidea; Majidae; Libinia.
OX NCBI_TaxID=6807;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eyestalk;
RX PubMed=9783445; DOI=10.1007/bf02480375;
RA Liu L., Laufer H., Gogarten P.J., Wang M.;
RT "cDNA cloning of a mandibular organ inhibiting hormone from the spider crab
RT Libinia emarginata.";
RL Invertebr. Neurosci. 3:199-204(1997).
RN [2]
RP PROTEIN SEQUENCE OF 63-134, PYROGLUTAMATE FORMATION AT GLN-63, AND MASS
RP SPECTROMETRY.
RC TISSUE=Sinus gland;
RX PubMed=9299429; DOI=10.1006/bbrc.1997.6977;
RA Liu L., Laufer H., Wang Y., Hayes T.;
RT "A neurohormone regulating both methyl farnesoate synthesis and glucose
RT metabolism in a crustacean.";
RL Biochem. Biophys. Res. Commun. 237:694-701(1997).
CC -!- FUNCTION: Represses the synthesis of methyl farnesoate, the precursor
CC of insect juvenile hormone III in the mandibular organ. Also has
CC hyperglycemic activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC eyestalks and transported to the sinus gland where it is stored and
CC released.
CC -!- MASS SPECTROMETRY: [Mandibular organ-inhibiting hormone]: Mass=8492.5;
CC Mass_error=3; Method=MALDI; Evidence={ECO:0000269|PubMed:9299429};
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305}.
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DR EMBL; AF144660; AAD32706.1; -; mRNA.
DR PIR; JC5628; JC5628.
DR AlphaFoldDB; P56688; -.
DR SMR; P56688; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR005558; Crust_neurhormone_H.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR InterPro; IPR001166; Hyperglycemic.
DR InterPro; IPR000346; Hyperglycemic1.
DR PANTHER; PTHR35981; PTHR35981; 1.
DR Pfam; PF03858; Crust_neuro_H; 1.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR PRINTS; PR00548; HYPRGLYCEMC1.
DR PRINTS; PR00550; HYPRGLYCEMIC.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PEPTIDE 27..60
FT /note="MOIH precursor-related peptide"
FT /id="PRO_0000019084"
FT CHAIN 63..134
FT /note="Mandibular organ-inhibiting hormone"
FT /id="PRO_0000019085"
FT MOD_RES 63
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:9299429"
FT MOD_RES 134
FT /note="Valine amide"
FT /evidence="ECO:0000255"
FT DISULFID 69..105
FT /evidence="ECO:0000250"
FT DISULFID 85..101
FT /evidence="ECO:0000250"
FT DISULFID 88..114
FT /evidence="ECO:0000250"
SQ SEQUENCE 137 AA; 15370 MW; CEE6656DF29CD353 CRC64;
MTTKCTVMAV VLAACICLQV LPQAYGRSTQ GYGRMDKLLA TLMGSSEGGA LESASQHSLE
KRQIFDPSCK GLYDRGLFSD LEHVCKDCYN LYRNPQVTSA CRVNCYSNRV FRQCMEDLLL
MEDFDKYARA IQTVGKK
