MOMA1_CAEEL
ID MOMA1_CAEEL Reviewed; 201 AA.
AC Q21154;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=MICOS complex subunit MIC27 {ECO:0000250|UniProtKB:Q6UXV4};
DE AltName: Full=Mitochondrial outer membrane abnormal protein 1 {ECO:0000303|PubMed:21248201};
DE Flags: Precursor;
GN Name=moma-1 {ECO:0000303|PubMed:21248201, ECO:0000312|WormBase:K02F3.10};
GN ORFNames=K02F3.10 {ECO:0000312|WormBase:K02F3.10};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=21248201; DOI=10.1091/mbc.e10-07-0600;
RA Head B.P., Zulaika M., Ryazantsev S., van der Bliek A.M.;
RT "A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae
RT morphology in Caenorhabditis elegans.";
RL Mol. Biol. Cell 22:831-841(2011).
CC -!- FUNCTION: Sustains mitochondrial morphology probably through
CC maintaining cristae morphology (PubMed:21248201). May act as a
CC component of the MICOS complex, a large protein complex of the
CC mitochondria (By similarity). {ECO:0000250|UniProtKB:Q6UXV4,
CC ECO:0000269|PubMed:21248201}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250|UniProtKB:Q6UXV4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:21248201}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos.
CC {ECO:0000269|PubMed:21248201}.
CC -!- DISRUPTION PHENOTYPE: Abnormal mitochondrial morphology with localized
CC swellings and tubular extensions, and distended cristae. Double
CC knockout with fzo-1 or eat-3 RNAi results in mitochondrial
CC fragmentation. Double knockout with chch-3 results in reduced or no
CC brood, poor growth and withered gonads which on a cellular level
CC contain fewer mitochondria. {ECO:0000269|PubMed:21248201}.
CC -!- SIMILARITY: Belongs to the apolipoprotein O/MICOS complex subunit Mic27
CC family. {ECO:0000305}.
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DR EMBL; BX284603; CCD61877.1; -; Genomic_DNA.
DR PIR; T16534; T16534.
DR RefSeq; NP_497275.1; NM_064874.3.
DR AlphaFoldDB; Q21154; -.
DR STRING; 6239.K02F3.10; -.
DR EPD; Q21154; -.
DR PaxDb; Q21154; -.
DR PeptideAtlas; Q21154; -.
DR EnsemblMetazoa; K02F3.10.1; K02F3.10.1; WBGene00019333.
DR GeneID; 175243; -.
DR KEGG; cel:CELE_K02F3.10; -.
DR UCSC; K02F3.10; c. elegans.
DR CTD; 175243; -.
DR WormBase; K02F3.10; CE01346; WBGene00019333; moma-1.
DR eggNOG; KOG4798; Eukaryota.
DR GeneTree; ENSGT00530000063666; -.
DR HOGENOM; CLU_090106_0_0_1; -.
DR InParanoid; Q21154; -.
DR OMA; AEQTWYS; -.
DR OrthoDB; 1605767at2759; -.
DR PhylomeDB; Q21154; -.
DR Reactome; R-CEL-114608; Platelet degranulation.
DR PRO; PR:Q21154; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00019333; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:WormBase.
DR GO; GO:0042407; P:cristae formation; IBA:GO_Central.
DR InterPro; IPR019166; MIC26/MIC27.
DR InterPro; IPR033182; MIC26/MIC27_animal.
DR PANTHER; PTHR14564; PTHR14564; 1.
DR Pfam; PF09769; ApoO; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..31
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 32..201
FT /note="MICOS complex subunit MIC27"
FT /evidence="ECO:0000305"
FT /id="PRO_0000438527"
FT TOPO_DOM 32..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:21248201"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..145
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305|PubMed:21248201"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:21248201"
SQ SEQUENCE 201 AA; 22082 MW; 83F9B3670D0C2E77 CRC64;
MTQDKPIVET ISNAGEQVTN VFGQFWQLVT SKNTTNNGDS KPIKIEQLPI YAEDNAPLKQ
KFLPEEPLPL QREFATIRIA CEQEYDRVAE RFKVVDCAMT QTKKAATKCN AYLTEEWTAL
PKAAAITVGG MAGFVLGLKR GPVGRLLTTT IGLATMAAFC YPIEAVDVAK TGRAHAEQTW
YSFQESPTPS AIVKTNLSPP K
