MOMAS_ORYSJ
ID MOMAS_ORYSJ Reviewed; 274 AA.
AC Q7FAE1; A3ARJ5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Momilactone A synthase;
DE Short=OsMAS;
DE EC=1.1.1.295;
GN OrderedLocusNames=Os04g0179200, LOC_Os04g10010;
GN ORFNames=OsJ_13988, OSJNBa0052P16.9;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP INDUCTION.
RX PubMed=12005050; DOI=10.1271/bbb.66.566;
RA Atawong A., Hasegawa M., Kodama O.;
RT "Biosynthesis of rice phytoalexin: enzymatic conversion of 3beta-hydroxy-
RT 9beta-pimara-7,15-dien-19,6beta-olide to momilactone A.";
RL Biosci. Biotechnol. Biochem. 66:566-570(2002).
RN [8]
RP FUNCTION, AND INDUCTION.
RX PubMed=17872948; DOI=10.1074/jbc.m703344200;
RA Shimura K., Okada A., Okada K., Jikumaru Y., Ko K.-W., Toyomasu T.,
RA Sassa T., Hasegawa M., Kodama O., Shibuya N., Koga J., Nojiri H.,
RA Yamane H.;
RT "Identification of a biosynthetic gene cluster in rice for momilactones.";
RL J. Biol. Chem. 282:34013-34018(2007).
CC -!- FUNCTION: Involved in momilactone phytoalexins biosynthesis. Catalyzes
CC the last step of momilactone A biosynthesis.
CC {ECO:0000269|PubMed:17872948}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) =
CC H(+) + momilactone A + NADH; Xref=Rhea:RHEA:25363, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:49191, ChEBI:CHEBI:49195, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.1.1.295;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+)
CC = H(+) + momilactone A + NADPH; Xref=Rhea:RHEA:25367,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:49191, ChEBI:CHEBI:49195,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.295;
CC -!- INDUCTION: By chitin oligosaccharide elicitor and UV irradiation.
CC {ECO:0000269|PubMed:12005050, ECO:0000269|PubMed:17872948}.
CC -!- MISCELLANEOUS: The phytoalexins momilactones A and B are diterpenoid
CC secondary metabolites involved in the defense mechanism of the plant
CC and produced in response to attack (by a pathogen, elicitor or UV
CC irradiation). Momilactone B can also act as an allochemical (an
CC antimicrobial and allelopathic agent), being constitutively produced in
CC the root of the plant and secreted to the rhizosphere where it
CC suppresses the growth of neighboring plants and soil microorganisms.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AL662936; CAD39722.3; -; Genomic_DNA.
DR EMBL; AP008210; BAF14088.1; -; Genomic_DNA.
DR EMBL; AP014960; BAS87952.1; -; Genomic_DNA.
DR EMBL; CM000141; EAZ29934.1; -; Genomic_DNA.
DR EMBL; AK103462; BAG96093.1; -; mRNA.
DR EMBL; AK106087; BAG97558.1; -; mRNA.
DR RefSeq; XP_015634207.1; XM_015778721.1.
DR AlphaFoldDB; Q7FAE1; -.
DR SMR; Q7FAE1; -.
DR STRING; 4530.OS04T0179200-01; -.
DR PaxDb; Q7FAE1; -.
DR PRIDE; Q7FAE1; -.
DR EnsemblPlants; Os04t0179200-01; Os04t0179200-01; Os04g0179200.
DR GeneID; 4335093; -.
DR Gramene; Os04t0179200-01; Os04t0179200-01; Os04g0179200.
DR KEGG; osa:4335093; -.
DR eggNOG; KOG0725; Eukaryota.
DR HOGENOM; CLU_010194_1_0_1; -.
DR InParanoid; Q7FAE1; -.
DR OMA; SMRYELP; -.
DR OrthoDB; 1053465at2759; -.
DR BioCyc; MetaCyc:MON-13863; -.
DR BRENDA; 1.1.1.295; 4460.
DR PlantReactome; R-OSA-1119308; Momilactone biosynthesis.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000007752; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR ExpressionAtlas; Q7FAE1; baseline and differential.
DR Genevisible; Q7FAE1; OS.
DR GO; GO:0102960; F:momilactone-A synthase activity; IEA:UniProtKB-EC.
DR CDD; cd05326; secoisolariciresinol-DH_like_SDR_c; 1.
DR InterPro; IPR045309; ABA2-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW NAD; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..274
FT /note="Momilactone A synthase"
FT /id="PRO_0000372311"
FT CONFLICT 125
FT /note="N -> Y (in Ref. 5; EAZ29934)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="H -> N (in Ref. 5; EAZ29934)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 274 AA; 27833 MW; 256ED89DD5FF707D CRC64;
MAAGSSHVSA DARKLVGKVA VITGGASGIG ACTARLFVKH GARVVVADIQ DELGASLVAE
LGPDASSYVH CDVTNEGDVA AAVDHAVARF GKLDVMFNNA GVSGPPCFRM SECTKEDFER
VLAVNLVGPF LGTKHAARVM APARRGSIIS TASLSSSVSG AASHAYTTSK HALVGFTENA
AGELGRHGIR VNCVSPAGVA TPLARAAMGM DDEAIEAIMA NSANLKGAGA LKADDIAAAA
LFLASDDGRY VSGQNLRVDG GLSVVNSSFG FFRD
