ID   MOMPA_CHLPS             Reviewed;         402 AA.
AC   P10332;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Major outer membrane porin;
DE            Short=MOMP;
DE   Flags: Precursor;
GN   Name=ompA; Synonyms=omp1;
OS   Chlamydia psittaci (Chlamydophila psittaci).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83554;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A22/M;
RX   AGRICOLA=IND89005865;
RA   Pickett M.A., Everson S.J., Clarke I.N.;
RT   "Chlamydia psittaci ewe abortion agent: complete nucleotide sequence of the
RT   major outer membrane protein gene.";
RL   FEMS Microbiol. Lett. 55:229-234(1988).
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the large cysteine-rich periplasmic
CC       protein. It has been described in publications as the Sarkosyl-
CC       insoluble COMC (Chlamydia outer membrane complex), and serves as the
CC       functional equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Permits diffusion of specific solutes through the outer
CC       membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin, the small cysteine-rich
CC       protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: It is present but some of the disulfide bonds are
CC       reduced in the intracellular reticulate bodies (RBs).
CC   -!- SIMILARITY: Belongs to the chlamydial porin (CP) (TC 1.B.2) family.
CC       {ECO:0000305}.
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DR   EMBL; X12647; CAA31177.1; -; Genomic_DNA.
DR   EMBL; M36703; AAA23146.1; -; Genomic_DNA.
DR   PIR; S05954; MMCWPM.
DR   RefSeq; WP_014947003.1; NZ_JACAAQ010000030.1.
DR   AlphaFoldDB; P10332; -.
DR   STRING; 331636.G5O_0062; -.
DR   TCDB; 1.B.2.1.1; the chlamydial porin (cp) family.
DR   eggNOG; ENOG502ZVFZ; Bacteria.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000604; Major_OMP_Chlamydia.
DR   Pfam; PF01308; Chlam_OMP; 1.
DR   PRINTS; PR01334; CHLAMIDIAOMP.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..402
FT                   /note="Major outer membrane porin"
FT                   /id="PRO_0000020142"
SQ   SEQUENCE   402 AA;  43277 MW;  E6CF00D9DF1EE87A CRC64;
     MKKLLKSALL FAATGSALSL QALPVGNPAE PSLLIDGTMW EGASGDPCDP CATWCDAISI
     RAGYYGDYVF DRVLKVDVNK TFSGMAATPT QATGNASNTN QPEANGRPNI AYGRHMQDAE
     WFSNAAFLAL NIWDRFDIFC TLGASNGYFK SSSAAFNLVG LIGFSATSST STELPMQLPN
     VGITQGVVEF YTDTSFSWSV GARGALWECG CATLGAEFQY AQSNPKIEVL NVTSSPAQFV
     IHKPRGYKGA SSNFPLPITA GTTEATDTKS ATIKYHEWQV GLALSYRLNM LVPYIGVNWS
     RATFDADTIR IAQPKLKSEI LNITTWNPSL LGSTTTLPNN GGKDVLSDVL QIASIQINKM
     KSRKACGVAV GATLIDADKW SITGEARLIN ERAAHMNAQF RF