ID   MOMP_CHLAB              Reviewed;         389 AA.
AC   P16567; Q5L762;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Major outer membrane porin;
DE            Short=MOMP;
DE   Flags: Precursor;
GN   Name=ompA; Synonyms=omp1; OrderedLocusNames=CAB048;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=2612883; DOI=10.1016/0378-1097(89)90383-2;
RA   Herring A.J., Tan T.W., Baxter S., Inglis N.F., Dunbar S.;
RT   "Sequence analysis of the major outer membrane protein gene of an ovine
RT   abortion strain of Chlamydia psittaci.";
RL   FEMS Microbiol. Lett. 53:153-158(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bovine abortion isolate BA1;
RX   PubMed=8605581; DOI=10.1016/s0007-1935(95)80149-9;
RA   Griffiths P.C., Plater J.M., Martin T.C., Hughes S.L., Hughes K.J.,
RA   Hewinson R.G., Dawson M.;
RT   "Epizootic bovine abortion in a dairy herd: characterization of a Chlamydia
RT   psittaci isolate and antibody response.";
RL   Br. Vet. J. 151:683-693(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the large cysteine-rich periplasmic
CC       protein. It has been described in publications as the Sarkosyl-
CC       insoluble COMC (Chlamydia outer membrane complex), and serves as the
CC       functional equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Permits diffusion of specific solutes through the outer
CC       membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin (MOMP), the small cysteine-
CC       rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC       (OmcB).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: It is present but some of the disulfide bonds are
CC       reduced in reticulate bodies (RBs).
CC   -!- SIMILARITY: Belongs to the chlamydial porin (CP) (TC 1.B.2) family.
CC       {ECO:0000305}.
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DR   EMBL; X51859; CAA36152.1; -; Genomic_DNA.
DR   EMBL; L39020; AAB02850.1; -; Genomic_DNA.
DR   EMBL; CR848038; CAH63506.1; -; Genomic_DNA.
DR   PIR; S08770; MMCWP3.
DR   RefSeq; WP_011096793.1; NC_004552.2.
DR   AlphaFoldDB; P16567; -.
DR   EnsemblBacteria; CAH63506; CAH63506; CAB048.
DR   KEGG; cab:CAB048; -.
DR   eggNOG; ENOG502ZVFZ; Bacteria.
DR   HOGENOM; CLU_693881_0_0_0; -.
DR   OMA; SGDPCDP; -.
DR   OrthoDB; 536772at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR000604; Major_OMP_Chlamydia.
DR   Pfam; PF01308; Chlam_OMP; 1.
DR   PRINTS; PR01334; CHLAMIDIAOMP.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Cell shape; Disulfide bond; Ion transport; Membrane;
KW   Porin; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT   CHAIN           23..389
FT                   /note="Major outer membrane porin"
FT                   /id="PRO_0000020138"
SQ   SEQUENCE   389 AA;  41884 MW;  741B5A23ACDBB447 CRC64;
     MKKLLKSALL FAATGSALSL QALPVGNPAE PSLLIDGTMW EGASGDPCDP CSTWCDAISI
     RAGYYGDYVF DRVLKVDVNK TITGMGAVPT GTAAANYKTP TDRPNIAYGK HLQDAEWFTN
     AAFLALNIWD RFDIFCTLGA SNGYFKASSA AFNLVGLIGV KGSSIAADQL PNVGITQGIV
     EFYTDTTFSW SVGARGALWE CGCATLGAEF QYAQSNPKIE MLNVVSSPAQ FVVHKPRGYK
     GTAFPLPLTA GTDQATDTKS ATIKYHEWQV GLALSYRLNM LVPYISVNWS RATFDADAIR
     IAQPKLAAAV LNLTTWNPTL LGEATALDTS NKFADFLQIA SIQINKMKSR KACGVAVGAT
     LIDADKWSIT GEARLINERA AHMNAQFRF