MOMP_CHLPN
ID MOMP_CHLPN Reviewed; 389 AA.
AC P27455; Q6LDD2; Q9JQF6;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Major outer membrane porin;
DE Short=MOMP;
DE Flags: Precursor;
GN Name=ompA; Synonyms=omp1; OrderedLocusNames=CPn_0695, CP_0051, CpB0722;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=IOL-207;
RX PubMed=2033374; DOI=10.1099/00221287-137-3-465;
RA Carter M.W., Al-Mahdawi S.A.H., Giles I.G., Treharne J.D., Ward M.E.,
RA Clarke I.N.;
RT "Nucleotide sequence and taxonomic value of the major outer membrane
RT protein gene of Chlamydia pneumoniae IOL-207.";
RL J. Gen. Microbiol. 137:465-475(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=TWAR;
RX PubMed=1840574; DOI=10.1128/iai.59.6.2195-2199.1991;
RA Perez Melgosa M., Kuo C.-C., Campbell L.A.;
RT "Sequence analysis of the major outer membrane protein gene of Chlamydia
RT pneumoniae.";
RL Infect. Immun. 59:2195-2199(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9484408; DOI=10.1212/wnl.50.2.571;
RA Sriram S., Mitchell W., Stratton C.;
RT "Multiple sclerosis associated with Chlamydia pneumoniae infection of the
RT CNS.";
RL Neurology 50:571-572(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10839753; DOI=10.1086/315616;
RA Shirai M., Hirakawa H., Ouchi K., Tabuchi M., Kishi F., Kimoto M.,
RA Takeuchi H., Nishida J., Shibata K., Fujinaga R., Yoneda H., Matsushima H.,
RA Tanaka C., Furukawa S., Miura K., Nakazawa A., Ishii K., Shiba T.,
RA Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of outer membrane protein genes omp and pmp in the whole genome
RT sequences of Chlamydia pneumoniae isolates from Japan and the United
RT States.";
RL J. Infect. Dis. 181 Suppl. 3:S524-S527(2000).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-352.
RX PubMed=1339411; DOI=10.1128/iai.60.12.5319-5323.1992;
RA Gaydos C.A., Quinn T.C., Bobo L.D., Eiden J.J.;
RT "Similarity of Chlamydia pneumoniae strains in the variable domain IV
RT region of the major outer membrane protein gene.";
RL Infect. Immun. 60:5319-5323(1992).
CC -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC able to survive outside the host cell) provides the structural
CC integrity of the outer envelope through disulfide cross-links with the
CC small cysteine-rich protein and the large cysteine-rich periplasmic
CC protein. It has been described in publications as the Sarkosyl-
CC insoluble COMC (Chlamydia outer membrane complex), and serves as the
CC functional equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Permits diffusion of specific solutes through the outer
CC membrane. {ECO:0000250}.
CC -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC composed of the major outer membrane porin (MOMP), the small cysteine-
CC rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC (OmcB).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: It is present but some of the disulfide bonds are
CC reduced in reticulate bodies (RBs).
CC -!- SIMILARITY: Belongs to the chlamydial porin (CP) (TC 1.B.2) family.
CC {ECO:0000305}.
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DR EMBL; M64064; AAA23143.1; -; Genomic_DNA.
DR EMBL; M69230; AAA73071.1; -; Genomic_DNA.
DR EMBL; AF131889; AAD22492.1; -; Genomic_DNA.
DR EMBL; AE001363; AAD18834.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF37944.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98902.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98651.1; -; Genomic_DNA.
DR EMBL; S50607; AAB24363.1; -; Genomic_DNA.
DR PIR; A43587; A43587.
DR PIR; D86577; D86577.
DR RefSeq; NP_224891.1; NC_000922.1.
DR RefSeq; WP_010883333.1; NZ_LN847257.1.
DR AlphaFoldDB; P27455; -.
DR STRING; 115711.CP_0051; -.
DR EnsemblBacteria; AAD18834; AAD18834; CPn_0695.
DR EnsemblBacteria; AAF37944; AAF37944; CP_0051.
DR GeneID; 45050746; -.
DR KEGG; cpa:CP_0051; -.
DR KEGG; cpj:ompA; -.
DR KEGG; cpn:CPn_0695; -.
DR KEGG; cpt:CpB0722; -.
DR PATRIC; fig|115713.3.peg.769; -.
DR eggNOG; ENOG502ZVFZ; Bacteria.
DR HOGENOM; CLU_693881_0_0_0; -.
DR OrthoDB; 536772at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IDA:CAFA.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0020003; C:symbiont-containing vacuole; IDA:CAFA.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR000604; Major_OMP_Chlamydia.
DR Pfam; PF01308; Chlam_OMP; 1.
DR PRINTS; PR01334; CHLAMIDIAOMP.
PE 2: Evidence at transcript level;
KW Cell outer membrane; Cell shape; Disulfide bond; Ion transport; Membrane;
KW Porin; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..23
FT CHAIN 24..389
FT /note="Major outer membrane porin"
FT /id="PRO_0000020140"
SQ SEQUENCE 389 AA; 41620 MW; 15D984151E41F8F2 CRC64;
MKKLLKSALL SAAFAGSVGS LQALPVGNPS DPSLLIDGTI WEGAAGDPCD PCATWCDAIS
LRAGFYGDYV FDRILKVDAP KTFSMGAKPT GSAAANYTTA VDRPNPAYNK HLHDAEWFTN
AGFIALNIWD RFDVFCTLGA SNGYIRGNST AFNLVGLFGV KGTTVNANEL PNVSLSNGVV
ELYTDTSFSW SVGARGALWE CGCATLGAEF QYAQSKPKVE ELNVICNVSQ FSVNKPKGYK
GVAFPLPTDA GVATATGTKS ATINYHEWQV GASLSYRLNS LVPYIGVQWS RATFDADNIR
IAQPKLPTAV LNLTAWNPSL LGNATALSTT DSFSDFMQIV SCQINKFKSR KACGVTVGAT
LVDADKWSLT AEARLINERA AHVSGQFRF
