ID   MON1A_BOVIN             Reviewed;         555 AA.
AC   Q17QV2; Q5E9N7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Vacuolar fusion protein MON1 homolog A;
GN   Name=MON1A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in membrane trafficking through the
CC       secretory apparatus. Not involved in endocytic trafficking to
CC       lysosomes. Acts in concert with CCZ1, as a guanine exchange factor
CC       (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from
CC       an inactive GDP-bound form into an active GTP-bound form.
CC       {ECO:0000250|UniProtKB:Q6PDG8, ECO:0000250|UniProtKB:Q86VX9}.
CC   -!- SUBUNIT: Interacts with CCZ1 (By similarity). Found in a complex with
CC       RMC1, CCZ1, MON1A and MON1B (By similarity). The MON1A-CCZ1B complex
CC       interacts with RIMOC1 (By similarity). The MON1A-CCZ1B complex
CC       interacts with RAB7A and this interaction is enhanced in the presence
CC       of RIMOC1 (By similarity). {ECO:0000250|UniProtKB:Q86VX9}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; BT020883; AAX08900.1; -; mRNA.
DR   EMBL; BC118164; AAI18165.1; -; mRNA.
DR   RefSeq; NP_001015623.1; NM_001015623.1.
DR   AlphaFoldDB; Q17QV2; -.
DR   SMR; Q17QV2; -.
DR   STRING; 9913.ENSBTAP00000026711; -.
DR   PaxDb; Q17QV2; -.
DR   PRIDE; Q17QV2; -.
DR   Ensembl; ENSBTAT00000026711; ENSBTAP00000026711; ENSBTAG00000020047.
DR   GeneID; 520286; -.
DR   KEGG; bta:520286; -.
DR   CTD; 84315; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020047; -.
DR   VGNC; VGNC:31552; MON1A.
DR   eggNOG; KOG0997; Eukaryota.
DR   GeneTree; ENSGT00390000006665; -.
DR   HOGENOM; CLU_014574_1_1_1; -.
DR   InParanoid; Q17QV2; -.
DR   OMA; TNSTCEY; -.
DR   OrthoDB; 829786at2759; -.
DR   TreeFam; TF314665; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000020047; Expressed in choroid plexus and 103 other tissues.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome.
FT   CHAIN           1..555
FT                   /note="Vacuolar fusion protein MON1 homolog A"
FT                   /id="PRO_0000285760"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VX9"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PDG8"
FT   MOD_RES         61
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VX9"
FT   MOD_RES         91
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VX9"
FT   CONFLICT        388..389
FT                   /note="DT -> EA (in Ref. 1; AAX08900)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   555 AA;  61760 MW;  2D09F46FEA926FF8 CRC64;
     MAADMQRKRS SEGPDGTLAP SDGQSVERAE SPTPGLAQGM EPGAGQEGAM FVHARSYEDL
     TESEDGAASG ESPKEGAGGP PPLATDMRQI SQDFSELSTQ LTGVARDLQE EMLPGSSEDW
     PESPGAARRP ATEPPRDGAG EGDEEEAAEA WRRHQKHVFV LSEAGKPVYS RYGSEEALSS
     TMGVMVALVS FLEADKNAIR SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY
     YQILSLLTGA QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA
     AVRDVVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN LISSSSSFRE
     GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR EDFFAVSDCR RRFQERLRKR
     GAHLALREAL RTPYYSVAQV GVPDLRHFLY KSKSSGLFTS PEIEAPYDSE EEQERLLGLY
     QYLHSRAHNA SRPLKTIYYT GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI
     RKEEDRLFIL TPLTY