ID   MON1A_MACFA             Reviewed;         555 AA.
AC   Q95KG9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Vacuolar fusion protein MON1 homolog A;
GN   Name=MON1A; ORFNames=QtrA-12666;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in membrane trafficking through the
CC       secretory apparatus. Not involved in endocytic trafficking to
CC       lysosomes. Acts in concert with CCZ1, as a guanine exchange factor
CC       (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from
CC       an inactive GDP-bound form into an active GTP-bound form.
CC       {ECO:0000250|UniProtKB:Q6PDG8, ECO:0000250|UniProtKB:Q86VX9}.
CC   -!- SUBUNIT: Interacts with CCZ1 (By similarity). Found in a complex with
CC       RMC1, CCZ1, MON1A and MON1B (By similarity). The MON1A-CCZ1B complex
CC       interacts with RIMOC1 (By similarity). The MON1A-CCZ1B complex
CC       interacts with RAB7A and this interaction is enhanced in the presence
CC       of RIMOC1 (By similarity). {ECO:0000250|UniProtKB:Q86VX9}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB46888.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB060880; BAB46888.1; ALT_INIT; mRNA.
DR   RefSeq; XP_005547223.1; XM_005547166.2.
DR   RefSeq; XP_005547224.1; XM_005547167.2.
DR   RefSeq; XP_015301412.1; XM_015445926.1.
DR   RefSeq; XP_015301413.1; XM_015445927.1.
DR   AlphaFoldDB; Q95KG9; -.
DR   SMR; Q95KG9; -.
DR   STRING; 9541.XP_005547220.1; -.
DR   GeneID; 102126726; -.
DR   CTD; 84315; -.
DR   eggNOG; KOG0997; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome.
FT   CHAIN           1..555
FT                   /note="Vacuolar fusion protein MON1 homolog A"
FT                   /id="PRO_0000285762"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VX9"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PDG8"
FT   MOD_RES         61
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VX9"
FT   MOD_RES         91
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VX9"
SQ   SEQUENCE   555 AA;  61934 MW;  8273652B837D05F4 CRC64;
     MAADMQRKRS SECPDGTLTP SDGHSVERAE SPTPGLAQGM EPGAGQEGAM FVHARSYEDL
     TESEDGAASG DSPKEGARGP PPLPADMRQI SQDFSELSTQ LTGVARDLQE EMLPGSSEDW
     LDPPGAVGRP ATEPPREGTA EGDEEDATEA WRLHQKHVFV LSEAGKPVYS RYGSEEALSS
     TMGVMVALVS FLEADKNAIR SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY
     YQILSLLTGA QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA
     AVRDTVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN LISSSSSFRE
     GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLFVSTDR EDFFAVSDCR RRFQERLRKR
     GAHLALREAL RTPYYSVAQV GIPDLRHFLY KSKSSGLFTS PEIEAPYTSE EEQERLLGLY
     QYLHSRAHNA SRPLKTIYYT GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI
     RKEEDRLFIL TPLTY