MON1B_MOUSE
ID MON1B_MOUSE Reviewed; 553 AA.
AC Q8BMQ8; Q69ZX1; Q6P5V5;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Vacuolar fusion protein MON1 homolog B;
GN Name=Mon1b; Synonyms=Kiaa0872;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-553.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-553.
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
CC -!- SUBUNIT: Interacts with CCNT2; down-regulates CCNT2-mediated activation
CC of viral promoters during herpes simplex virus 1/HHV-1 infection. Found
CC in a complex with RMC1, CCZ1 MON1A and MON1B.
CC {ECO:0000250|UniProtKB:Q7L1V2}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR EMBL; AK030288; BAC26880.1; -; mRNA.
DR EMBL; BC062639; AAH62639.1; -; mRNA.
DR EMBL; AK173047; BAD32325.1; -; mRNA.
DR CCDS; CCDS22685.1; -.
DR RefSeq; NP_001041608.1; NM_001048143.2.
DR RefSeq; NP_766603.1; NM_173015.3.
DR AlphaFoldDB; Q8BMQ8; -.
DR SMR; Q8BMQ8; -.
DR BioGRID; 234759; 4.
DR STRING; 10090.ENSMUSP00000045089; -.
DR PhosphoSitePlus; Q8BMQ8; -.
DR EPD; Q8BMQ8; -.
DR MaxQB; Q8BMQ8; -.
DR PaxDb; Q8BMQ8; -.
DR PeptideAtlas; Q8BMQ8; -.
DR PRIDE; Q8BMQ8; -.
DR ProteomicsDB; 290290; -.
DR Antibodypedia; 30376; 97 antibodies from 19 providers.
DR Ensembl; ENSMUST00000035777; ENSMUSP00000045089; ENSMUSG00000078908.
DR Ensembl; ENSMUST00000179926; ENSMUSP00000137605; ENSMUSG00000078908.
DR GeneID; 270096; -.
DR KEGG; mmu:270096; -.
DR UCSC; uc009nnn.2; mouse.
DR CTD; 22879; -.
DR MGI; MGI:1923231; Mon1b.
DR VEuPathDB; HostDB:ENSMUSG00000078908; -.
DR eggNOG; KOG0997; Eukaryota.
DR GeneTree; ENSGT00390000006665; -.
DR HOGENOM; CLU_014574_4_1_1; -.
DR InParanoid; Q8BMQ8; -.
DR OMA; TKTCAIT; -.
DR OrthoDB; 829786at2759; -.
DR PhylomeDB; Q8BMQ8; -.
DR TreeFam; TF314665; -.
DR Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR BioGRID-ORCS; 270096; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Mon1b; mouse.
DR PRO; PR:Q8BMQ8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BMQ8; protein.
DR Bgee; ENSMUSG00000078908; Expressed in animal zygote and 212 other tissues.
DR Genevisible; Q8BMQ8; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; ISS:UniProtKB.
DR GO; GO:0019085; P:early viral transcription; ISO:MGI.
DR GO; GO:0019086; P:late viral transcription; ISO:MGI.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; PTHR13027; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 2: Evidence at transcript level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..553
FT /note="Vacuolar fusion protein MON1 homolog B"
FT /id="PRO_0000285767"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q7L1V2"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L1V2"
SQ SEQUENCE 553 AA; 60016 MW; 84AF288D8126A10D CRC64;
MEAGGDNAVP APGGVEDLVD TQFPREEAGD SERVHASTLD PGDGDPEDTG SKDQPSSLLS
PLPQTEAASS TCEHWETAAA SDSSPPGEPE SNSEGQGEDP DDGGDPSDED WRSQRKHVFV
LSEAGKPIYS RYGSVEALSA TMGVMTALVS FVQSAGDAIR AIYAEDHKLV FLQQGPLLLV
AVSRTPQSAA QLRGELLAVH AQIVSTLTRA SVARIFAHKQ NYDLRRLLAG SERTLDRLLD
SVEQDPGALL LGAVRCVPLA RPLRDALGTL LRRCTAPGLA LSVLAVGGRL ITVAQERNVL
AECRLDPADL QLLLDWVGAP AFAAGEAWAP VCLPRFNPDG FFYAYVARLD SMPVCLLLLG
TNREAFHAMA ACRRLVEDGM HNLGALRTLG EAANFSNGPA ASAPAYSVQA VGAPGLRHFL
YKPLDIPEQH RQLPQFTSPE LEAPYSREEE RQRLSDLYHR LHARLHSTSR PLRLIYHVAE
KETLLAWVTS KFELYTCLSP LVTKAGAILV VTKLLRWVRK EEDRLFIRYP PKYSTPPSTS
ADQAPNNGLF TGL
