ID   MON1_ASPCL              Reviewed;         630 AA.
AC   A1CEH4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Vacuolar fusion protein mon1;
GN   Name=mon1; ORFNames=ACLA_089650;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1 family. {ECO:0000305}.
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DR   EMBL; DS027052; EAW11273.1; -; Genomic_DNA.
DR   RefSeq; XP_001272699.1; XM_001272698.1.
DR   AlphaFoldDB; A1CEH4; -.
DR   SMR; A1CEH4; -.
DR   STRING; 5057.CADACLAP00008171; -.
DR   EnsemblFungi; EAW11273; EAW11273; ACLA_089650.
DR   GeneID; 4705342; -.
DR   KEGG; act:ACLA_089650; -.
DR   VEuPathDB; FungiDB:ACLA_089650; -.
DR   eggNOG; KOG0997; Eukaryota.
DR   HOGENOM; CLU_014574_5_0_1; -.
DR   OMA; TNSTCEY; -.
DR   OrthoDB; 829786at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..630
FT                   /note="Vacuolar fusion protein mon1"
FT                   /id="PRO_0000278852"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   630 AA;  69089 MW;  AE10530EA8CBDB1B CRC64;
     MNSKASEQPQ VSPGDNEHAQ DGSTSCAKNC ARYTNDDASA ALEERLPPLP PRPSTLSFLD
     EGYTSSRSIR QTSQVNLQAK ATTAVSLTDI GFRQSSEGDG EDHSAPDFPE PLRAKASLNQ
     PKTSKGSDAG DSTSIGSTIP NVELGEVENV FSDFLAAEPS APQEDGSGLL QFPEFRADDA
     EDEFATEFEP IGDLNEQGEN EELLLERWKS KRKHYLILSA AGKPIWTRHG DGGLISGYVG
     VIQTIISFYE DAKDHLSSFC AGDTKFVVIT RGPLHLVAIS RLHESDTQLK SQLEALYMQI
     LSTLTLPSLT HLFSVRPSTD LKRPLQGSET LLSTLADSFT KGSPSSLLSA LECLKIRKSH
     RQAINNALLK TRVGSLLYGL VVAGGRLVSV VRPKKHSLHP GDLQLLFNMI FEAEGVKAGG
     GENWIPVCLP GFNSSGYLYM YVSFLDLRED SGSTANETAT KEESVAIILI STKKESFFEL
     QGMRNAFVEQ MDKNESIKII KEAIKRGRPT TTDIVPGTVL HHFLYKSRAN VQFTMSAYGP
     ESSSTFRLRR LMSTYNDLHS SVHAKHAHVK VHHCVSQSTS SFAWVTPRFE LYCVASPNAN
     RNALAQSASK IVQWVQQEEE RLFIIGGAVF